4v2u
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Apo-structure of alpha2,3-sialyltransferase from Pasteurella dagmatis== | |
| + | <StructureSection load='4v2u' size='340' side='right'caption='[[4v2u]], [[Resolution|resolution]] 2.71Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4v2u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pasteurella_dagmatis Pasteurella dagmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V2U FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2u OCA], [https://pdbe.org/4v2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v2u RCSB], [https://www.ebi.ac.uk/pdbsum/4v2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2u ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/K9UUI6_9PAST K9UUI6_9PAST] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Structure-guided active-site redesign of a family GT-80 beta-D-galactoside sialyltransferase (from Pasteurella dagmatis) to change enzyme regioselectivity from alpha-2,3 in the wild type to alpha-2,6 in a P7H-M117A double mutant is reported. Biochemical data for sialylation of lactose together with protein crystal structures demonstrate highly precise enzyme engineering. | ||
| - | + | Complete switch from alpha-2,3- to alpha-2,6-regioselectivity in Pasteurella dagmatis beta-D-galactoside sialyltransferase by active-site redesign.,Schmolzer K, Czabany T, Luley-Goedl C, Pavkov-Keller T, Ribitsch D, Schwab H, Gruber K, Weber H, Nidetzky B Chem Commun (Camb). 2015 Feb 21;51(15):3083-6. doi: 10.1039/c4cc09772f. PMID:25619424<ref>PMID:25619424</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4v2u" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Sialyltransferase 3D structures|Sialyltransferase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pasteurella dagmatis]] | ||
| + | [[Category: Czabany T]] | ||
| + | [[Category: Gruber K]] | ||
| + | [[Category: Luley-Goedl C]] | ||
| + | [[Category: Nidetzky B]] | ||
| + | [[Category: Pavkov-Keller T]] | ||
| + | [[Category: Ribitsch D]] | ||
| + | [[Category: Schmoelzer K]] | ||
| + | [[Category: Schwab H]] | ||
Current revision
Apo-structure of alpha2,3-sialyltransferase from Pasteurella dagmatis
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