4v3i
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4v3i is ON HOLD until Paper Publication Authors: Jeong, J.H., Kim, Y.G. Description: Crystal Structure of TssL from Vibrio cholerae.) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of TssL from Vibrio cholerae.== | |
| + | <StructureSection load='4v3i' size='340' side='right'caption='[[4v3i]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4v3i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V3I FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.499Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v3i OCA], [https://pdbe.org/4v3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v3i RCSB], [https://www.ebi.ac.uk/pdbsum/4v3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v3i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9KN50_VIBCH Q9KN50_VIBCH] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The type VI secretion system (T6SS), commonly found in gram-negative bacteria, is responsible for exporting effector proteins. The T6SS has been reported to be cytotoxic to host cells. While the components and assembly of the T6SS complex have been largely assessed, structural data on T6SS components from virulent bacteria is remarkably insufficient. Here, we report the crystal structure of Vibrio cholerae TssL (VcTssL), a core component of T6SS. In spite of a relatively low sequence identity, the overall structure of VcTssL is largely similar to those from other bacterial homologs except for several differences found in local structural elements. A unique feature attributed to the C-terminal fragment of VcTssL is a crystallographic artifact. This incidental feature of VcTssL may provide insights into screening of molecular partners for the cytoplasmic domain of TssL. Additionally, our results may help in the design of molecular probes for a detailed understanding of the functional relationship between TssL and other T6SS components. | ||
| - | + | Crystal structure of the bacterial type VI secretion system component TssL from Vibrio cholerae.,Chang JH, Kim YG J Microbiol. 2014 Dec 4. PMID:25471186<ref>PMID:25471186</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4v3i" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vibrio cholerae]] | ||
| + | [[Category: Jeong JH]] | ||
| + | [[Category: Kim YG]] | ||
Current revision
Crystal Structure of TssL from Vibrio cholerae.
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