4whw

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'''Unreleased structure'''
 
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The entry 4whw is ON HOLD until Paper Publication
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==Direct photocapture of bromodomains using tropolone chemical probes==
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<StructureSection load='4whw' size='340' side='right'caption='[[4whw]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4whw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WHW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.345&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3OT:2-METHOXY-4-{1-[2-(MORPHOLIN-4-YL)ETHYL]-2-(2-PHENYLETHYL)-1H-BENZIMIDAZOL-5-YL}CYCLOHEPTA-2,4,6-TRIEN-1-ONE'>3OT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whw OCA], [https://pdbe.org/4whw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4whw RCSB], [https://www.ebi.ac.uk/pdbsum/4whw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4whw ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Authors: Hett, E.C., Piatnitski Chekler, E.L., Basak, A., Bonin, P.D., Denny, R.A., Flick, A.C., Geoghegan, K.F., Liu, S., Pletcher, M.T., Robinson, R.P., Sahasrabudhe, P., Salter, S., Stock, I.A., Jones, L.H.
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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Description: Direct photocapture of bromodomains using tropolone chemical probes
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Basak A]]
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[[Category: Bonin PD]]
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[[Category: Denny RA]]
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[[Category: Flick AC]]
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[[Category: Geoghegan KF]]
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[[Category: Hett EC]]
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[[Category: Jones LH]]
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[[Category: Liu S]]
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[[Category: Piatnitski Chekler EL]]
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[[Category: Pletcher MT]]
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[[Category: Robinson RP]]
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[[Category: Sahasrabudhe P]]
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[[Category: Salter S]]
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[[Category: Stock IA]]

Current revision

Direct photocapture of bromodomains using tropolone chemical probes

PDB ID 4whw

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