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1k37

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[[Image:1k37.jpg|left|200px]]
 
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{{Structure
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==NMR Structure of human Epiregulin==
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|PDB= 1k37 |SIZE=350|CAPTION= <scene name='initialview01'>1k37</scene>
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<StructureSection load='1k37' size='340' side='right'caption='[[1k37]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1k37]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K37 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k37 OCA], [https://pdbe.org/1k37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k37 RCSB], [https://www.ebi.ac.uk/pdbsum/1k37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k37 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''NMR Structure of human Epiregulin'''
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[https://www.uniprot.org/uniprot/EREG_HUMAN EREG_HUMAN] Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.<ref>PMID:9419975</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Epiregulin (EPR), a novel member of epidermal growth factor (EGF) family, is a ligand for ErbB-1 and ErbB-4 receptors. The binding affinity of EPR for the receptors is lower than those of other EGF-family ligands. The solution structure of EPR was determined using two-dimensional nuclear magnetic resonance spectroscopy. The secondary structure in the C-terminal domain of EPR is different from other EGF-family ligands because of the lack of hydrogen bonds. The structural difference in the C-terminal domain may provide an explanation for the reduced binding affinity of EPR to the ErbB receptors.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k3/1k37_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1K37 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K37 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k37 ConSurf].
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Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity., Sato K, Nakamura T, Mizuguchi M, Miura K, Tada M, Aizawa T, Gomi T, Miyamoto K, Kawano K, FEBS Lett. 2003 Oct 23;553(3):232-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14572630 14572630]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aizawa, T.]]
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[[Category: Aizawa T]]
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[[Category: Kawano, K.]]
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[[Category: Kawano K]]
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[[Category: Miura, K.]]
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[[Category: Miura K]]
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[[Category: Miyamoto, K.]]
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[[Category: Miyamoto K]]
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[[Category: Sato, K.]]
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[[Category: Sato K]]
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[[Category: Tada, M.]]
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[[Category: Tada M]]
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[[Category: egf-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:11:59 2008''
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Current revision

NMR Structure of human Epiregulin

PDB ID 1k37

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