2mom
From Proteopedia
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==Structural insights of TM domain of LAMP-2A in DPC micelles== | ==Structural insights of TM domain of LAMP-2A in DPC micelles== | ||
| - | <StructureSection load='2mom' size='340' side='right' caption='[[2mom | + | <StructureSection load='2mom' size='340' side='right'caption='[[2mom]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mom]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOM OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[2mom]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MOM FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mom OCA], [https://pdbe.org/2mom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mom RCSB], [https://www.ebi.ac.uk/pdbsum/2mom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mom ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/LAMP2_HUMAN LAMP2_HUMAN] Glycogen storage disease due to LAMP-2 deficiency. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/LAMP2_HUMAN LAMP2_HUMAN] Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.<ref>PMID:8407947</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rout A]] |
| - | [[Category: | + | [[Category: Tjandra N]] |
Current revision
Structural insights of TM domain of LAMP-2A in DPC micelles
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