4qj2

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==Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with WT p1-p6 substrate==
==Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with WT p1-p6 substrate==
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<StructureSection load='4qj2' size='340' side='right' caption='[[4qj2]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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<StructureSection load='4qj2' size='340' side='right'caption='[[4qj2]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qj2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QJ2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qj2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QJ2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qj6|4qj6]], [[4qj7|4qj7]], [[4qj8|4qj8]], [[4qj9|4qj9]], [[4qja|4qja]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qj2 OCA], [https://pdbe.org/4qj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qj2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qj2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qj2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qj2 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O38710_9HIV1 O38710_9HIV1]
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==See Also==
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*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: HIV-1 retropepsin]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Lin, K H.]]
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[[Category: Large Structures]]
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[[Category: Schiffer, C A.]]
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[[Category: Lin KH]]
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[[Category: Co-evolution]]
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[[Category: Schiffer CA]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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Current revision

Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with WT p1-p6 substrate

PDB ID 4qj2

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