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3aem

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==Reaction intermediate structure of Entamoeba histolytica methionine gamma-lyase 1 containing Michaelis complex and methionine imine-pyridoxamine-5'-phosphate==
==Reaction intermediate structure of Entamoeba histolytica methionine gamma-lyase 1 containing Michaelis complex and methionine imine-pyridoxamine-5'-phosphate==
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<StructureSection load='3aem' size='340' side='right' caption='[[3aem]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='3aem' size='340' side='right'caption='[[3aem]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3aem]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AEM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3aem]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AEM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LM:(2E)-2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)IMINO]-4-(METHYLSULFANYL)BUTANOIC+ACID'>2LM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2LM:(2E)-2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)IMINO]-4-(METHYLSULFANYL)BUTANOIC+ACID'>2LM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3acz|3acz]], [[3aej|3aej]], [[3ael|3ael]], [[3aen|3aen]], [[3aeo|3aeo]], [[3aep|3aep]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aem OCA], [https://pdbe.org/3aem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aem RCSB], [https://www.ebi.ac.uk/pdbsum/3aem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aem ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">metg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5759 Entamoeba histolytica])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_gamma-lyase Methionine gamma-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.11 4.4.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aem OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aem RCSB], [http://www.ebi.ac.uk/pdbsum/3aem PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q86D28_ENTHI Q86D28_ENTHI]
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==See Also==
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*[[Methionine gamma-lyase 3D structures|Methionine gamma-lyase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Entamoeba histolytica]]
[[Category: Entamoeba histolytica]]
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[[Category: Methionine gamma-lyase]]
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[[Category: Large Structures]]
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[[Category: Harada, S.]]
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[[Category: Harada S]]
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[[Category: Karaki, T.]]
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[[Category: Karaki T]]
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[[Category: Nozaki, T.]]
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[[Category: Nozaki T]]
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[[Category: Sato, D.]]
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[[Category: Sato D]]
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[[Category: Shimizu, A.]]
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[[Category: Shimizu A]]
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[[Category: Entamoeba histolytica]]
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[[Category: Gamma-lyase]]
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[[Category: L-methionine]]
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[[Category: Lyase]]
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Current revision

Reaction intermediate structure of Entamoeba histolytica methionine gamma-lyase 1 containing Michaelis complex and methionine imine-pyridoxamine-5'-phosphate

PDB ID 3aem

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