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1k7b

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[[Image:1k7b.jpg|left|200px]]
 
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{{Structure
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==NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva==
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|PDB= 1k7b |SIZE=350|CAPTION= <scene name='initialview01'>1k7b</scene>
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<StructureSection load='1k7b' size='340' side='right'caption='[[1k7b]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1k7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K7B FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k7b OCA], [https://pdbe.org/1k7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k7b RCSB], [https://www.ebi.ac.uk/pdbsum/1k7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k7b ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva'''
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[https://www.uniprot.org/uniprot/RSVR_COTJA RSVR_COTJA] Responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The cellular receptor for subgroup A avian leukosis and sarcoma virus (ALSV-A) is Tva, which contains a motif related to repeats in the low density lipoprotein receptor (LDLR) ligand binding repeat (LBr) and which is necessary for viral entry. As observed with LBr repeats of LDLR, the 47 residue LBr domain of Tva (sTva47) requires calcium during oxidative folding to form the correct disulfide bonds, and calcium enhances the structure of correctly oxidized sTva47, as well as its ability to bind the viral envelope protein (Env). However, solution nuclear magnetic resonance studies indicate that, even in the presence of excess calcium, sTva47 exists in an ensemble of conformations. Nonetheless, as reported here, the structure of the predominant sTva47 solution conformer closely resembles that of other LBr repeats, with identical S-S binding topology and octahedral calcium coordination. The location of W48 and other critical residues on the surface suggests a region of the molecule necessary for Env binding and to mediate post-binding events important for ALSV-A cell entry.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/1k7b_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1K7B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Coturnix_coturnix Coturnix coturnix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K7B OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k7b ConSurf].
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The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus., Tonelli M, Peters RJ, James TL, Agard DA, FEBS Lett. 2001 Dec 7;509(2):161-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11768384 11768384]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Coturnix coturnix]]
[[Category: Coturnix coturnix]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Agard, D A.]]
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[[Category: Agard DA]]
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[[Category: James, T L.]]
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[[Category: James TL]]
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[[Category: Peters, R J.]]
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[[Category: Peters RJ]]
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[[Category: Tonelli, M.]]
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[[Category: Tonelli M]]
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[[Category: 3-10 helix]]
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[[Category: beta hairpin]]
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[[Category: calcium binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:13:34 2008''
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Current revision

NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva

PDB ID 1k7b

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