4r8g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Myosin-1c tail in complex with Calmodulin== | |
| + | <StructureSection load='4r8g' size='340' side='right'caption='[[4r8g]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4r8g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R8G FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.503Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8g OCA], [https://pdbe.org/4r8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r8g RCSB], [https://www.ebi.ac.uk/pdbsum/4r8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r8g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MYO1C_MOUSE MYO1C_MOUSE] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.<ref>PMID:16971510</ref> Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. | ||
| - | + | ==See Also== | |
| - | + | *[[Calmodulin 3D structures|Calmodulin 3D structures]] | |
| - | + | *[[Myosin 3D Structures|Myosin 3D Structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Li J]] | ||
| + | [[Category: Lu Q]] | ||
| + | [[Category: Ye F]] | ||
| + | [[Category: Zhang M]] | ||
Current revision
Crystal Structure of Myosin-1c tail in complex with Calmodulin
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Categories: Large Structures | Mus musculus | Xenopus laevis | Li J | Lu Q | Ye F | Zhang M
