We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

3ahq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:46, 4 October 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==hyperactive human Ero1==
==hyperactive human Ero1==
-
<StructureSection load='3ahq' size='340' side='right' caption='[[3ahq]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
+
<StructureSection load='3ahq' size='340' side='right'caption='[[3ahq]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3ahq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AHQ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3ahq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AHQ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rp4|1rp4]], [[3ahr|3ahr]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ero1-Lalpha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ahq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ahq OCA], [https://pdbe.org/3ahq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ahq RCSB], [https://www.ebi.ac.uk/pdbsum/3ahq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ahq ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ahq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ahq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ahq RCSB], [http://www.ebi.ac.uk/pdbsum/3ahq PDBsum]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ERO1A_HUMAN ERO1A_HUMAN] Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.<ref>PMID:10671517</ref> <ref>PMID:10970843</ref> <ref>PMID:11707400</ref> <ref>PMID:12403808</ref> <ref>PMID:18833192</ref> <ref>PMID:18971943</ref> <ref>PMID:23027870</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 16: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3ahq" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
Line 21: Line 24:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Inaba, K.]]
+
[[Category: Large Structures]]
-
[[Category: Sitia, R.]]
+
[[Category: Inaba K]]
-
[[Category: Suzuki, M.]]
+
[[Category: Sitia R]]
-
[[Category: Disulfide bond]]
+
[[Category: Suzuki M]]
-
[[Category: Hyperactive human ero1]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Pdi]]
+
-
[[Category: Redox]]
+

Current revision

hyperactive human Ero1

PDB ID 3ahq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ahq"
Personal tools