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1kg7

From Proteopedia

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[[Image:1kg7.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of the E161A mutant of E.coli MutY (core fragment)==
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|PDB= 1kg7 |SIZE=350|CAPTION= <scene name='initialview01'>1kg7</scene>, resolution 1.50&Aring;
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<StructureSection load='1kg7' size='340' side='right'caption='[[1kg7]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[1kg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KG7 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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|GENE= mutY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kg7 OCA], [https://pdbe.org/1kg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1kg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kg7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MUTY_ECOLI MUTY_ECOLI] Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kg7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kg7 ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of the E161A mutant of E.coli MutY (core fragment)'''
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==See Also==
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1KG7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KG7 OCA].
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gerchman, S E.]]
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[[Category: Gerchman SE]]
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[[Category: Gilboa, R.]]
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[[Category: Gilboa R]]
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[[Category: Grollman, A P.]]
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[[Category: Grollman AP]]
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[[Category: Kilshtein, A.]]
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[[Category: Kilshtein A]]
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[[Category: Kycia, J H.]]
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[[Category: Kycia JH]]
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[[Category: Shoham, G.]]
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[[Category: Shoham G]]
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[[Category: Zharkov, D O.]]
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[[Category: Zharkov DO]]
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[[Category: GOL]]
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[[Category: SF4]]
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[[Category: SO4]]
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[[Category: dna repair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:17:06 2008''
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Current revision

Crystal Structure of the E161A mutant of E.coli MutY (core fragment)

PDB ID 1kg7

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