2i1y

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==Crystal structure of the phosphatase domain of human PTP IA-2==
==Crystal structure of the phosphatase domain of human PTP IA-2==
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<StructureSection load='2i1y' size='340' side='right' caption='[[2i1y]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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<StructureSection load='2i1y' size='340' side='right'caption='[[2i1y]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2i1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I1Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2i1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPRN, ICA3, ICA512 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1y OCA], [https://pdbe.org/2i1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1y RCSB], [https://www.ebi.ac.uk/pdbsum/2i1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1y ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2i1y TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i1y RCSB], [http://www.ebi.ac.uk/pdbsum/2i1y PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2i1y TOPSAN]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1y_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1y_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1y ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2i1y" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Alvarado, J]]
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[[Category: Alvarado J]]
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[[Category: Atwell, S]]
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[[Category: Atwell S]]
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[[Category: Bain, K T]]
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[[Category: Bain KT]]
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[[Category: Burley, S K]]
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[[Category: Burley SK]]
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[[Category: Faber-Barata, J]]
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[[Category: Faber-Barata J]]
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[[Category: Freeman, M]]
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[[Category: Freeman M]]
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[[Category: Kearins, M C]]
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[[Category: Kearins MC]]
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[[Category: Koss, J]]
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[[Category: Koss J]]
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[[Category: Maletic, M]]
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[[Category: Maletic M]]
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[[Category: Structural genomic]]
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[[Category: Ozyurt S]]
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[[Category: Ozyurt, S]]
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[[Category: Patskovsky Y]]
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[[Category: Patskovsky, Y]]
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[[Category: Powell A]]
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[[Category: Powell, A]]
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[[Category: Rooney I]]
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[[Category: Rooney, I]]
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[[Category: Russell JC]]
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[[Category: Russell, J C]]
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[[Category: Smith D]]
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[[Category: Smith, D]]
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[[Category: Thompson DA]]
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[[Category: Thompson, D A]]
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[[Category: Wasserman SR]]
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[[Category: Wasserman, S R]]
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[[Category: Hydrolase]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: Phosphatase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Receptor-type protein tyrosine phosphatase precursor]]
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Current revision

Crystal structure of the phosphatase domain of human PTP IA-2

PDB ID 2i1y

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