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| | ==Structure of Bitistatin B== | | ==Structure of Bitistatin B== |
| - | <StructureSection load='2mp5' size='340' side='right' caption='[[2mp5]], [[NMR_Ensembles_of_Models | 43 NMR models]]' scene=''> | + | <StructureSection load='2mp5' size='340' side='right'caption='[[2mp5]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2mp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bitis_arietans Bitis arietans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MP5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2mp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bitis_arietans Bitis arietans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MP5 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mop|2mop]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 43 models</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mp5 RCSB], [http://www.ebi.ac.uk/pdbsum/2mp5 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp5 OCA], [https://pdbe.org/2mp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mp5 RCSB], [https://www.ebi.ac.uk/pdbsum/2mp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mp5 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
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| | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| | </div> | | </div> |
| | + | <div class="pdbe-citations 2mp5" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Disintegrin|Disintegrin]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Bitis arietans]] | | [[Category: Bitis arietans]] |
| - | [[Category: Calvete, J]] | + | [[Category: Large Structures]] |
| - | [[Category: Carbajo, R J]] | + | [[Category: Calvete J]] |
| - | [[Category: Perez, A]] | + | [[Category: Carbajo RJ]] |
| - | [[Category: Sanz, L]] | + | [[Category: Perez A]] |
| - | [[Category: Bitis arietan]] | + | [[Category: Sanz L]] |
| - | [[Category: Disintegrin]]
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| - | [[Category: Snake venom]]
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| - | [[Category: Toxin]]
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| Structural highlights
Publication Abstract from PubMed
Extant disintegrins represent a family of polypeptides found in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes) that block potently and with high degree of selectivity the function of beta1 and beta3 integrin receptors. This toxin family owes its origin to the neofunctionalization of the extracellular region of an ADAM molecule recruited into the snake venom gland proteome in the Jurassic. The evolutionary structural diversification of the disintegrin scaffold, from the ancestral long disintegrins to the more recently evolved medium-sized, dimeric, and short disintegrins, involved the stepwise loss of pairs of class-specific disulfide linkages and the processing of the N-terminal region. NMR and crystal structures of medium-sized, dimeric, and short disintegrins have been solved. However, the structure of a long disintegrin was missing. The here reported NMR solution structures of two disulfide bond conformers of the long disintegrin bitistatin, from the African puff adder Bitis arietans, provide insights into how a structural domain of the extracellular region of an ADAM molecule recruited, and selectively expressed into the snake venom gland proteome as a PIII metalloprotease in the Jurassic has been since tranformed into a family of integrin receptor antagonists. This article is protected by copyright. All rights reserved.
NMR structure of bitistatin, a missing piece in the evolutionary pathway of snake venom disintegrins.,Carbajo RJ, Sanz L, Perez A, Calvete JJ FEBS J. 2014 Nov 1. doi: 10.1111/febs.13138. PMID:25363287[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Carbajo RJ, Sanz L, Perez A, Calvete JJ. NMR structure of bitistatin, a missing piece in the evolutionary pathway of snake venom disintegrins. FEBS J. 2014 Nov 1. doi: 10.1111/febs.13138. PMID:25363287 doi:http://dx.doi.org/10.1111/febs.13138
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