3u0y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:45, 14 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP==
==Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP==
-
<StructureSection load='3u0y' size='340' side='right' caption='[[3u0y]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+
<StructureSection load='3u0y' size='340' side='right'caption='[[3u0y]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3u0y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U0Y FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3u0y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0Y FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTI:1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)PIPERAZINE'>GTI</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ioh|3ioh]], [[3ioi|3ioi]], [[3ioj|3ioj]], [[3u0x|3u0x]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTI:1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)PIPERAZINE'>GTI</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u0y RCSB], [http://www.ebi.ac.uk/pdbsum/3u0y PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0y OCA], [https://pdbe.org/3u0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0y RCSB], [https://www.ebi.ac.uk/pdbsum/3u0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0y ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
 +
 +
==See Also==
 +
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Jorgensen, R]]
+
[[Category: Homo sapiens]]
-
[[Category: Palcic, M M]]
+
[[Category: Large Structures]]
-
[[Category: Semi closed conformation]]
+
[[Category: Jorgensen R]]
-
[[Category: Abo]]
+
[[Category: Palcic MM]]
-
[[Category: Blood group antigen]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Glycosyltransferase]]
+
-
[[Category: H-antigen acceptor]]
+
-
[[Category: Manganese]]
+
-
[[Category: Membrane]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Rossmann fold]]
+
-
[[Category: Transferase]]
+
-
[[Category: Transferase gtb]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+
-
[[Category: Udp-gal]]
+

Current revision

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP

PDB ID 3u0y

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools