4r8p

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==Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle==
==Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle==
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<StructureSection load='4r8p' size='340' side='right' caption='[[4r8p]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
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<StructureSection load='4r8p' size='340' side='right'caption='[[4r8p]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r8p]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R8P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r8p]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R8P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2846&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r8p RCSB], [http://www.ebi.ac.uk/pdbsum/4r8p PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8p OCA], [https://pdbe.org/4r8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r8p RCSB], [https://www.ebi.ac.uk/pdbsum/4r8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r8p ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4r8p" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
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*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
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*[[Polycomb proteins|Polycomb proteins]]
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Henrici, R C]]
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[[Category: Homo sapiens]]
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[[Category: McGinty, R K]]
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[[Category: Large Structures]]
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[[Category: Tan, S]]
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[[Category: Synthetic construct]]
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[[Category: Arginine anchor]]
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[[Category: Xenopus laevis]]
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[[Category: Histone modification enzyme]]
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[[Category: Henrici RC]]
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[[Category: Ring domain]]
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[[Category: McGinty RK]]
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[[Category: Structural protein-dna complex]]
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[[Category: Tan S]]
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[[Category: Ubiquitin ligase]]
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Current revision

Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle

PDB ID 4r8p

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