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1kzq

From Proteopedia

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[[Image:1kzq.jpg|left|200px]]
 
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{{Structure
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==crystal structure of a parasite protein==
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|PDB= 1kzq |SIZE=350|CAPTION= <scene name='initialview01'>1kzq</scene>, resolution 1.7&Aring;
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<StructureSection load='1kzq' size='340' side='right'caption='[[1kzq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1kzq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KZQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE= SAG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 Toxoplasma gondii])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzq OCA], [https://pdbe.org/1kzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kzq RCSB], [https://www.ebi.ac.uk/pdbsum/1kzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kzq ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''crystal structure of a parasite protein'''
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[https://www.uniprot.org/uniprot/P30_TOXGO P30_TOXGO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. The 1.7 A structure of the immunodominant SAG1 antigen reveals a homodimeric configuration in which the dimeric interface is mediated by an extended beta-sheet that forms a deep groove lined with positively charged amino acids. This basic groove seems to be conserved among SRS proteins and potentially serves as a sulfated proteoglycan-binding site on target cell surfaces, thus rationalizing the promiscuous attachment properties of Toxoplasma to a broad range of host cell types.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kzq_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1KZQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZQ OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kzq ConSurf].
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Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily., He XL, Grigg ME, Boothroyd JC, Garcia KC, Nat Struct Biol. 2002 Aug;9(8):606-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12091874 12091874]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
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[[Category: Boothroyd, J C.]]
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[[Category: Boothroyd JC]]
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[[Category: Garcia, K C.]]
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[[Category: Garcia KC]]
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[[Category: Grigg, M E.]]
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[[Category: Grigg ME]]
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[[Category: He, X.]]
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[[Category: He X]]
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[[Category: crystal structure]]
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[[Category: mad]]
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[[Category: major surface antigen]]
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[[Category: parasite invasion]]
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[[Category: sag1]]
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[[Category: toxoplasma gondii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:24:21 2008''
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Current revision

crystal structure of a parasite protein

PDB ID 1kzq

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