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1l0q

From Proteopedia

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[[Image:1l0q.jpg|left|200px]]
 
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{{Structure
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==Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein==
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|PDB= 1l0q |SIZE=350|CAPTION= <scene name='initialview01'>1l0q</scene>, resolution 2.4&Aring;
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<StructureSection load='1l0q' size='340' side='right'caption='[[1l0q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1l0q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_mazei_S-6 Methanosarcina mazei S-6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L0Q FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0q OCA], [https://pdbe.org/1l0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l0q RCSB], [https://www.ebi.ac.uk/pdbsum/1l0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l0q ProSAT]</span></td></tr>
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</table>
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'''Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q50245_METMZ Q50245_METMZ]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The surface layer of archaeobacteria protects cells from extreme environments and, in Methanosarcina, may regulate cell adhesion. We identify three domain types that account for the complete architecture of numerous Methanosarcina surface layer proteins (SLPs). We solve the crystal structure for two of these domains, which correspond to the two N-terminal domains of an M. mazei SLP. One domain displays a unique, highly symmetrical, seven-bladed beta propeller fold, and the other belongs to the polycystic kidney disease (PKD) superfamily fold. The third domain is predicted to adopt a beta helix fold. These domains have homologs in metazoan cell surface proteins, suggesting remarkable relationships between domains in archaeal SLPs and metazoan cell surface proteins.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/1l0q_consurf.spt"</scriptWhenChecked>
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1L0Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaea Archaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Q OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins., Jing H, Takagi J, Liu JH, Lindgren S, Zhang RG, Joachimiak A, Wang JH, Springer TA, Structure. 2002 Oct;10(10):1453-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12377130 12377130]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l0q ConSurf].
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[[Category: Archaea]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Jing, H.]]
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</StructureSection>
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[[Category: Joachimiak, A.]]
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[[Category: Large Structures]]
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[[Category: Lindgren, S.]]
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[[Category: Methanosarcina mazei S-6]]
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[[Category: Liu, J H.]]
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[[Category: Jing H]]
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[[Category: Springer, T A.]]
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[[Category: Joachimiak A]]
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[[Category: Takagi, J.]]
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[[Category: Lindgren S]]
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[[Category: Wang, J H.]]
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[[Category: Liu J-H]]
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[[Category: Zhang, R G.]]
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[[Category: Springer TA]]
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[[Category: 7-bladed beta-propeller]]
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[[Category: Takagi J]]
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[[Category: pkd superfamily]]
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[[Category: Wang J-H]]
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[[Category: s-layer]]
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[[Category: Zhang R-G]]
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[[Category: slp]]
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[[Category: surface layer protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:24:56 2008''
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Current revision

Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein

PDB ID 1l0q

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