1l1p
From Proteopedia
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| - | [[Image:1l1p.jpg|left|200px]] | ||
| - | + | ==Solution Structure of the PPIase Domain from E. coli Trigger Factor== | |
| - | + | <StructureSection load='1l1p' size='340' side='right'caption='[[1l1p]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | | | + | <table><tr><td colspan='2'>[[1l1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1P FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1p OCA], [https://pdbe.org/1l1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1p RCSB], [https://www.ebi.ac.uk/pdbsum/1l1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1p ProSAT], [https://www.topsan.org/Proteins/BSGI/1l1p TOPSAN]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/TIG_ECOLI TIG_ECOLI] Involved in protein export. Acts as a chaperone by maintaining the newly synthesized secretory and non-secretory proteins in an open conformation. Binds to nascent polypeptide chains via ribosomal protein L23 (PubMed:12226666). Functions as a peptidyl-prolyl cis-trans isomerase in vitro, this activity is dispensible in vivo for chaperone activity.<ref>PMID:8633085</ref> <ref>PMID:8521806</ref> <ref>PMID:14726952</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | == | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1p_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1p ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Denisov A]] | |
| - | + | [[Category: Ekiel I]] | |
| - | [[Category: Denisov | + | [[Category: Gehring K]] |
| - | [[Category: Ekiel | + | [[Category: Ghandi S]] |
| - | [[Category: Gehring | + | [[Category: Kozlov G]] |
| - | [[Category: Ghandi | + | [[Category: Perreault A]] |
| - | [[Category: Kozlov | + | [[Category: Trempe J-F]] |
| - | [[Category: Perreault | + | [[Category: Wong M]] |
| - | [[Category: Trempe | + | |
| - | [[Category: Wong | + | |
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Current revision
Solution Structure of the PPIase Domain from E. coli Trigger Factor
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Categories: Escherichia coli | Large Structures | Denisov A | Ekiel I | Gehring K | Ghandi S | Kozlov G | Perreault A | Trempe J-F | Wong M
