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4rpu

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(New page: '''Unreleased structure''' The entry 4rpu is ON HOLD Authors: Mo, S.M., Liang, W.G., King, J.V., Wijaya, J., Koehler, C.M., Tang, W.J. Description: Crystal Structure of Human Presequen...)
Current revision (23:07, 26 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4rpu is ON HOLD
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==Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60==
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<StructureSection load='4rpu' size='340' side='right'caption='[[4rpu]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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Authors: Mo, S.M., Liang, W.G., King, J.V., Wijaya, J., Koehler, C.M., Tang, W.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4rpu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RPU FirstGlance]. <br>
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Description: Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.265&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UE:[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL](3-METHYL-4-NITROPHENYL)METHANONE'>3UE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rpu OCA], [https://pdbe.org/4rpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rpu RCSB], [https://www.ebi.ac.uk/pdbsum/4rpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rpu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PREP_HUMAN PREP_HUMAN] ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.<ref>PMID:16849325</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: King JV]]
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[[Category: Koehler CM]]
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[[Category: Liang WG]]
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[[Category: Mo SM]]
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[[Category: Tang WJ]]
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[[Category: Wijaya J]]

Current revision

Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60

PDB ID 4rpu

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