4rl2

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==Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins==
==Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins==
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<StructureSection load='4rl2' size='340' side='right' caption='[[4rl2]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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<StructureSection load='4rl2' size='340' side='right'caption='[[4rl2]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rl2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RL2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RL2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3S3:(1R)-2-({(R)-CARBOXY[(2R,5S)-4-CARBOXY-5-METHYL-5,6-DIHYDRO-2H-1,3-THIAZIN-2-YL]METHYL}AMINO)-2-OXO-1-PHENYLETHANAMINIUM'>3S3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.008&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3S3:(1R)-2-({(R)-CARBOXY[(2R,5S)-4-CARBOXY-5-METHYL-5,6-DIHYDRO-2H-1,3-THIAZIN-2-YL]METHYL}AMINO)-2-OXO-1-PHENYLETHANAMINIUM'>3S3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rl2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rl2 RCSB], [http://www.ebi.ac.uk/pdbsum/4rl2 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rl2 OCA], [https://pdbe.org/4rl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rl2 RCSB], [https://www.ebi.ac.uk/pdbsum/4rl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rl2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4rl2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Klebsiella pneumoniae]]
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[[Category: Ding, J]]
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[[Category: Large Structures]]
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[[Category: Feng, H]]
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[[Category: Ding J]]
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[[Category: Liu, W]]
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[[Category: Feng H]]
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[[Category: Liu, X]]
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[[Category: Liu W]]
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[[Category: Wang, D C]]
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[[Category: Liu X]]
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[[Category: Xu, X]]
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[[Category: Wang D-C]]
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[[Category: Zang, S]]
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[[Category: Xu X]]
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[[Category: Zhang, Y]]
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[[Category: Zang S]]
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[[Category: Zhu, D]]
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[[Category: Zhang Y]]
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[[Category: Hydrolase]]
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[[Category: Zhu D]]
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[[Category: Ndm-1 antibiotic hydrolysis]]
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Current revision

Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins

PDB ID 4rl2

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