1lis

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[[Image:1lis.jpg|left|200px]]
 
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{{Structure
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==THE CRYSTAL STRUCTURE OF A FERTILIZATION PROTEIN==
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|PDB= 1lis |SIZE=350|CAPTION= <scene name='initialview01'>1lis</scene>, resolution 1.9&Aring;
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<StructureSection load='1lis' size='340' side='right'caption='[[1lis]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1lis]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haliotis_rufescens Haliotis rufescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LIS FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lis OCA], [https://pdbe.org/1lis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lis RCSB], [https://www.ebi.ac.uk/pdbsum/1lis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lis ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELYS_HALRU ELYS_HALRU] Dissolves the egg vitelline layer nonenzymatically during fertilization. It creates a hole of about 3 mu-m in diameter through which the sperm pass.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/1lis_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lis ConSurf].
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<div style="clear:both"></div>
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'''THE CRYSTAL STRUCTURE OF A FERTILIZATION PROTEIN'''
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==See Also==
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*[[Lysin|Lysin]]
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*[[Lysin 3D structures|Lysin 3D structures]]
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==Overview==
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__TOC__
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Lysin, a protein from abalone sperm, creates a hole in the envelope of the egg, permitting the sperm to pass through the envelope and fuse with the egg. The structure of lysin, refined at 1.9 angstroms resolution, reveals an alpha-helical, amphipathic molecule. The surface of the protein exhibits three features: two tracks of basic residues that span the length of the molecule, a solvent-exposed cluster of aromatic and aliphatic amino acids, and an extended amino-terminal hypervariable domain that is species-specific. The structure suggests possible mechanisms of action.
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</StructureSection>
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==About this Structure==
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1LIS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haliotis_rufescens Haliotis rufescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIS OCA].
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==Reference==
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The crystal structure of lysin, a fertilization protein., Shaw A, McRee DE, Vacquier VD, Stout CD, Science. 1993 Dec 17;262(5141):1864-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8266073 8266073]
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[[Category: Haliotis rufescens]]
[[Category: Haliotis rufescens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Mcree, D E.]]
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[[Category: Mcree DE]]
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[[Category: Shaw, A.]]
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[[Category: Shaw A]]
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[[Category: Stout, C D.]]
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[[Category: Stout CD]]
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[[Category: Vacquier, V D.]]
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[[Category: Vacquier VD]]
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[[Category: fertilization protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:31:21 2008''
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Current revision

THE CRYSTAL STRUCTURE OF A FERTILIZATION PROTEIN

PDB ID 1lis

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