CD2-associated protein

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<StructureSection load='2j6o' size='350' side='right' caption='Structure of human CD2AP SH3 domain 1 (grey) complex with E3 ubiquitin ligase peptide (pink) (PDB entry [[2j6o]])' scene=''>
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<StructureSection load='2j6o' size='350' side='right' caption='Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (magenta) (PDB entry [[2j6o]])' scene='56/569738/Cv/1'>
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'''CD2-associated protein''' (CD2AP) called also '''CMS''', is a scaffolding protein which regulates actin cytoskeleton. CD2AP SH3 domain interacts with actin and a variety of membrane proteins. CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.
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__TOC__
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==3D structures of CD2-associated protein==
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== Function ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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'''CD2-associated protein''' (CD2AP) called also '''CMS''', is a scaffolding protein which regulates actin cytoskeleton. CD2AP SH3 domain interacts with actin and a variety of membrane proteins. CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.<ref>PMID:12354621</ref><ref>PMID:17020880</ref>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*CD2AP SH3 domain 1
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== Disease ==
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**[[2j6k]] – hCD2AP – human <br />
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Haploinsufficiency of CD2AP is associated with susceptibility of glomerular disease
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**[[2krm]] – mCD2AP – mouse - NMR <br />
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**[[2j6f]] – hCD2AP + E3 ubiquitin protein ligase peptide <br />
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**[[2j6o]], [[2j7i]] – hCD2AP + CD2 peptide <br />
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**[[2mcn]] - mCD2AP + ubiquitin <br />
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*CD2AP SH3 domain 2
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==3D structures of CD2-associated protein==
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[[CD2-associated protein 3D structures]]
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**[[2fei]] – hCD2AP – NMR<br />
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**[[3u23]] - hCD2AP + RIN3 proline-rich peptide<br />
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*CD2AP SH3 domain 3
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**[[2jte]], [[2kro]] – mCD2AP - NMR<br />
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**[[2lz6]] – hCD2AP + ubiquitin - NMR<br />
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*CD2AP proline-rich domain
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</StructureSection>
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**[[3lk4]], [[3aa6]] – hCD2AP + CapZ<br />
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== References ==
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}}
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<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (magenta) (PDB entry 2j6o)

Drag the structure with the mouse to rotate

References

  1. ↑ Dikic I. CIN85/CMS family of adaptor molecules. FEBS Lett. 2002 Oct 2;529(1):110-5. PMID:12354621
  2. ↑ Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J. Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880 doi:10.1074/jbc.M606411200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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