Tom almog/UCP1
From Proteopedia
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==Your Heading Here (maybe something like 'Structure')== | ==Your Heading Here (maybe something like 'Structure')== | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene='60/607861/Ucp1/1'> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene='60/607861/Ucp1/1'> | ||
| - | + | The uncoupling protein UCP1 is a member of a superfamily of homologous proteins formed by the mitochondrial metabolite transporters. | |
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| - | The uncoupling protein UCP1 is a member of a superfamily of homologous proteins formed by the | + | |
| - | mitochondrial metabolite transporters. | + | |
== Function == | == Function == | ||
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== Disease == | == Disease == | ||
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| + | Knockout of the UCP1 gene produces mice that are cold intolerant. | ||
== Relevance == | == Relevance == | ||
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UCP1 is composed of three repeated domains of approximately 100 amino acids each. | UCP1 is composed of three repeated domains of approximately 100 amino acids each. | ||
| - | + | Its activity is regulated by purine nucleotides (inhibitors) and non-esterified fatty acids (activators). | |
It proposes that in the protein core there must exist a hydrophilic translocation pore whose access is controlled by gates. It is highly likely that the hydrophilic channel is formed by the transmembrane á-helices and that loops contribute to the formation of the gates. | It proposes that in the protein core there must exist a hydrophilic translocation pore whose access is controlled by gates. It is highly likely that the hydrophilic channel is formed by the transmembrane á-helices and that loops contribute to the formation of the gates. | ||
| - | <scene name='60/607861/ | + | <scene name='60/607861/Ucp1_active_site/5'>UCP1's active site</scene> |
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Current revision
Your Heading Here (maybe something like 'Structure')
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