1lq1

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[[Image:1lq1.jpg|left|200px]]
 
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{{Structure
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==DNA Complexed Structure of the Key Transcription Factor Initiating Development in Sporulation Bacteria==
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|PDB= 1lq1 |SIZE=350|CAPTION= <scene name='initialview01'>1lq1</scene>, resolution 2.3&Aring;
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<StructureSection load='1lq1' size='340' side='right'caption='[[1lq1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1lq1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LQ1 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE= SPO0A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lq1 OCA], [https://pdbe.org/1lq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lq1 RCSB], [https://www.ebi.ac.uk/pdbsum/1lq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lq1 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''DNA Complexed Structure of the Key Transcription Factor Initiating Development in Sporulation Bacteria'''
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[https://www.uniprot.org/uniprot/SP0A_BACSU SP0A_BACSU] May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Sporulation in Bacillus species, the ultimate bacterial adaptive response, requires the precisely coordinated expression of a complex genetic pathway, and is initiated through the accumulation of the phosphorylated form of Spo0A, a pleiotropic response regulator transcription factor. Spo0A controls the transcription of several hundred genes in all spore-forming Bacilli including genes for sporulation and toxin regulation in pathogens such as Bacillus anthracis. The crystal structure of the effector domain of Spo0A from Bacillus subtilis in complex with its DNA target was determined. In the crystal lattice, two molecules form a tandem dimer upon binding to adjacent sites on DNA. The protein:protein and protein:DNA interfaces revealed in the crystal provide a basis for interpreting the transcription activation process and for the design of drugs to counter infections by these bacteria.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/1lq1_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1LQ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQ1 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lq1 ConSurf].
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DNA complexed structure of the key transcription factor initiating development in sporulating bacteria., Zhao H, Msadek T, Zapf J, Madhusudan, Hoch JA, Varughese KI, Structure. 2002 Aug;10(8):1041-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12176382 12176382]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hoch, J A.]]
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[[Category: Hoch JA]]
[[Category: Madhusudan]]
[[Category: Madhusudan]]
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[[Category: Msadek, T.]]
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[[Category: Msadek T]]
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[[Category: Varughese, K I.]]
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[[Category: Varughese KI]]
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[[Category: Zapf, J.]]
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[[Category: Zapf J]]
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[[Category: Zhao, H.]]
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[[Category: Zhao H]]
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[[Category: 0a box]]
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[[Category: dna complexed structure]]
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[[Category: spo0a]]
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[[Category: transcriptional activation and repression]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:33:50 2008''
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Current revision

DNA Complexed Structure of the Key Transcription Factor Initiating Development in Sporulation Bacteria

PDB ID 1lq1

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