4d6v
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4d6v is ON HOLD Authors: Ero, R., Dimitrova, V.T., Chen, Y., Bu, W., Feng, S., Liu, T., Wang, P., Xue, C., Tan, S.M., Gao, Y.G. Description: Crysta...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of signal transducing protein== | |
| + | <StructureSection load='4d6v' size='340' side='right'caption='[[4d6v]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4d6v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans_var._grubii_H99 Cryptococcus neoformans var. grubii H99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D6V FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6v OCA], [https://pdbe.org/4d6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d6v RCSB], [https://www.ebi.ac.uk/pdbsum/4d6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/J9W3X8_CRYNH J9W3X8_CRYNH] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The atypical Gbeta-like/RACK1 Gib2 protein promotes cAMP signalling that plays a central role in regulating the virulence of Cryptococcus neoformans. Gib2 contains a seven-bladed beta transducin structure and is emerging as a scaffold protein interconnecting signalling pathways through interactions with various protein partners. Here, we present the crystal structure of Gib2 at a 2.2-A resolution. The structure allows us to analyse the association between Gib2 and the ribosome, as well as to identify the Gib2 amino acid residues involved in ribosome binding. Our studies not only suggest that Gib2 has a role in protein translation but also present Gib2 as a physical link at the crossroads of various regulatory pathways important for the growth and virulence of C. neoformans. | ||
| - | + | Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans.,Ero R, Dimitrova VT, Chen Y, Bu W, Feng S, Liu T, Wang P, Xue C, Tan SM, Gao YG Sci Rep. 2015 Mar 3;5:8688. doi: 10.1038/srep08688. PMID:25732347<ref>PMID:25732347</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4d6v" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cryptococcus neoformans var. grubii H99]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bu W]] | ||
| + | [[Category: Chen Y]] | ||
| + | [[Category: Dimitrova VT]] | ||
| + | [[Category: Ero R]] | ||
| + | [[Category: Feng S]] | ||
| + | [[Category: Gao YG]] | ||
| + | [[Category: Liu T]] | ||
| + | [[Category: Tan SM]] | ||
| + | [[Category: Wang P]] | ||
| + | [[Category: Xue C]] | ||
Current revision
Crystal structure of signal transducing protein
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Categories: Cryptococcus neoformans var. grubii H99 | Large Structures | Bu W | Chen Y | Dimitrova VT | Ero R | Feng S | Gao YG | Liu T | Tan SM | Wang P | Xue C
