1lud

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[[Image:1lud.gif|left|200px]]
 
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{{Structure
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==SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES==
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|PDB= 1lud |SIZE=350|CAPTION= <scene name='initialview01'>1lud</scene>
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<StructureSection load='1lud' size='340' side='right'caption='[[1lud]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene>
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<table><tr><td colspan='2'>[[1lud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LUD FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lud OCA], [https://pdbe.org/1lud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lud RCSB], [https://www.ebi.ac.uk/pdbsum/1lud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lud ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_LACCA DYR_LACCA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lu/1lud_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lud ConSurf].
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<div style="clear:both"></div>
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'''SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES'''
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1LUD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUD OCA].
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[[Category: Lacticaseibacillus casei]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Birdsall B]]
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NMR-based solution structure of the complex of Lactobacillus casei dihydrofolate reductase with trimethoprim and NADPH., Polshakov VI, Smirnov EG, Birdsall B, Kelly G, Feeney J, J Biomol NMR. 2002 Sep;24(1):67-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12449420 12449420]
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[[Category: Feeney J]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Kelly G]]
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[[Category: Lactobacillus casei]]
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[[Category: Polshakov VI]]
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[[Category: Single protein]]
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[[Category: Smirnov EG]]
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[[Category: Birdsall, B.]]
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[[Category: Feeney, J.]]
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[[Category: Kelly, G.]]
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[[Category: Polshakov, V I.]]
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[[Category: Smirnov, E G.]]
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[[Category: NDP]]
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[[Category: TRR]]
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[[Category: dhfr]]
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[[Category: inhibitor/enzyme complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:35:17 2008''
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Current revision

SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES

PDB ID 1lud

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