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Insulin-like growth factor
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<StructureSection load='1gzr' size='400' side='right' caption='Structure of insulin-like growth factor I complex with detergent (PDB entry [[1gzr]])' scene=''> | <StructureSection load='1gzr' size='400' side='right' caption='Structure of insulin-like growth factor I complex with detergent (PDB entry [[1gzr]])' scene=''> | ||
| - | + | == Function == | |
| - | '''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme.<br /> | + | '''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme<ref>PMID:15797461</ref>.<br /> |
| - | * '''IGF I''' is secreted in the liver after stimulation by growth hormone.<br /> | + | * '''IGF I''' is secreted in the liver after stimulation by growth hormone. See details in [[IGF1]] and [[Igf1 - alec]].<br /> |
* '''IGF II''' is required in early development stages. | * '''IGF II''' is required in early development stages. | ||
| + | |||
| + | == Relevance == | ||
| + | Inhibition of IGF I influences colon cancer<ref>PMID:11694656</ref>. IGF I has protective effect in neuropathy<ref>PMID:15832492</ref>. | ||
| + | |||
| + | See also [[Insulin-like growth factor receptor]] and [[Insulin-like growth factor 1]]. | ||
| + | </StructureSection> | ||
==3D structures of insulin-like growth factor== | ==3D structures of insulin-like growth factor== | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *IGF I | + | *IGF I residues 49-118 |
| - | **[[2gf1]], [[3gf1]], [[1b9g]], [[1bqt]] – hIGF I – human – NMR<BR /> | + | **[[2gf1]], [[3gf1]], [[1b9g]], [[1bqt]], [[6rva]] – hIGF I – human – NMR<BR /> |
**[[3lri]] - hIGF I (mutant) – NMR<BR /> | **[[3lri]] - hIGF I (mutant) – NMR<BR /> | ||
| - | **[[1tgr]] - hIGF I (mutant) <BR /> | ||
**[[1imx]], [[1gzr]], [[1gzy]], [[1gzz]], [[1h02]] - hIGF I<BR /> | **[[1imx]], [[1gzr]], [[1gzy]], [[1gzz]], [[1h02]] - hIGF I<BR /> | ||
| + | **[[1tgr]] - hIGF I (mutant) <BR /> | ||
**[[1pmx]] – hIGF I + peptide - NMR<BR /> | **[[1pmx]] – hIGF I + peptide - NMR<BR /> | ||
**[[1h59]] – hIGF I + IGF binding protein 5<BR /> | **[[1h59]] – hIGF I + IGF binding protein 5<BR /> | ||
**[[2dsp]], [[2dsr]] - hIGF I + IGF binding protein 4<BR /> | **[[2dsp]], [[2dsr]] - hIGF I + IGF binding protein 4<BR /> | ||
**[[1wqj]] - hIGF I + IGF binding protein 4<br /> | **[[1wqj]] - hIGF I + IGF binding protein 4<br /> | ||
| - | **[[2dsq]] - hIGF I + IGF binding protein 4 + IGF binding protein 1 | + | **[[2dsq]] - hIGF I + IGF binding protein 4 + IGF binding protein 1<br /> |
| + | **[[4xss]] - hIGF I + insulin receptor + insulin-like growth factor receptor peptide<br /> | ||
| + | **[[5u8q]] - hIGF I + IGFI receptor + antibody<br /> | ||
| + | **[[6ff3]] - hIGF I + neural ectodermal development factor<br /> | ||
| + | **[[6pyh]] - hIGF I + mIGFI receptor – Cryo EM<br /> | ||
| + | **[[7wrq]] - hIGF I + IGFBP3 + ALS – Cryo EM<br /> | ||
| + | **[[7s0q]] - hIGF I + IGFI receptor + insulin receptor – Cryo EM<br /> | ||
| + | **[[8eyr]] - hIGF I 1-195 + IGFI receptor – Cryo EM<br /> | ||
| - | *IGF II | + | *IGF II residues 25-91 |
| - | **[[1igl]] - hIGF II – NMR<BR /> | + | **[[1igl]], [[5l3l]], [[5l3m]], [[5l3n]] - hIGF II – NMR<BR /> |
**[[3e4z]] – hIGF II + insulin-degrading enzyme<BR /> | **[[3e4z]] – hIGF II + insulin-degrading enzyme<BR /> | ||
| - | **[[ | + | **[[3kr3]] - hIGF II + antibody<br /> |
| + | **[[6um2]] - hIGF II + bIGFII receptor – Cryo EM<br /> | ||
| + | **[[6vwg]], [[6vwi]] - hIGF II + IGFI receptor – Cryo EM<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of insulin-like growth factor
Updated on 17-January-2024
References
- ↑ Wood AW, Duan C, Bern HA. Insulin-like growth factor signaling in fish. Int Rev Cytol. 2005;243:215-85. PMID:15797461 doi:http://dx.doi.org/10.1016/S0074-7696(05)43004-1
- ↑ Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001 Nov;131(11 Suppl):3109S-20S. PMID:11694656
- ↑ Mohamed-Ali V, Pinkney J. Therapeutic potential of insulin-like growth factor-1 in patients with diabetes mellitus. Treat Endocrinol. 2002;1(6):399-410. PMID:15832492
