Muconate cycloisomerase
From Proteopedia
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| - | + | <StructureSection load='3fyy' size='350' side='right' caption='Muconate cycloisomerase dimer complex with Mg+2 ion (green) (PDB entry [[3fyy]])' scene=''> | |
| - | '''Muconate cycloisomerase''' (MCI) catalyzes the formation of muconolactone from cis, cis-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds. | + | '''Muconate cycloisomerase''' (MCI) catalyzes the formation of muconolactone from ''cis,cis''-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds<ref>PMID:9726873</ref>. MCI breaks down lignin-derived catechol and protocatechuate. |
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| + | *'''Chloromuconate cycloisomerase''' catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to ''cis,cis''-butadiene-1,2,4-tricarboxylate <ref>PMID:7305906</ref>.<br /> | ||
| + | *'''3-carboxy-''cis,cis''-muconate cycloisomerase''' catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 3-chloro-''cis,cis''-muconate<ref>PMID:5916392</ref>.<br /> | ||
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| + | </StructureSection> | ||
== 3D Structures of muconate cycloisomerase == | == 3D Structures of muconate cycloisomerase == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *''' | + | *'''Chloro-MCI''' |
**[[2chr]] – MCI – ''Cupriavidsua necator''<br /> | **[[2chr]] – MCI – ''Cupriavidsua necator''<br /> | ||
| - | **[[1nu5]] - MCI – ''Pseudomonas'' | + | **[[1nu5]] - MCI – ''Pseudomonas''<br /> |
| + | **[[4m0x]] – MCI – ''Rhodococcus opacus''<br /> | ||
| - | *''' | + | *'''MCI''' |
**[[1muc]], [[1bkh]] – PbMCI – ''Pseudomonas putida''<br /> | **[[1muc]], [[1bkh]] – PbMCI – ''Pseudomonas putida''<br /> | ||
**[[3muc]], [[2muc]], [[1f9c]] – PbMCI (mutant) <br /> | **[[3muc]], [[2muc]], [[1f9c]] – PbMCI (mutant) <br /> | ||
| - | **[[3fyy]] – OiMCI – ''Oceanobacillus iheyensis''<br /> | + | **[[2oqy]], [[3fyy]] – OiMCI – ''Oceanobacillus iheyensis''<br /> |
**[[3i4k]] – MCI – ''Corynebacterium glutamicum''<br /> | **[[3i4k]] – MCI – ''Corynebacterium glutamicum''<br /> | ||
**[[3i6e]] – MCI – ''Ruegeria pomeroyi''<br /> | **[[3i6e]] – MCI – ''Ruegeria pomeroyi''<br /> | ||
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**[[2zad]] – TmMCI – ''Thermotoga maritima''<br /> | **[[2zad]] – TmMCI – ''Thermotoga maritima''<br /> | ||
**[[3ct2]] - PfMCI – ''Pseudomonas fluorescens''<br /> | **[[3ct2]] - PfMCI – ''Pseudomonas fluorescens''<br /> | ||
| - | **[[3dg3]] – MsMCI - ''Mycobacterium smegmatis'' | + | **[[3dg3]] – MsMCI - ''Mycobacterium smegmatis''<br /> |
| + | **[[3fcp]] – MCI – ''Klebsiella pneumoniae''<br /> | ||
| - | * | + | *MCI complexes |
**[[3es7]], [[3es8]] – OiMCI + Mg + malate<br /> | **[[3es7]], [[3es8]] – OiMCI + Mg + malate<br /> | ||
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**[[1q5n]] – MCI – ''Acinetobacter calcoaceticus''<br /> | **[[1q5n]] – MCI – ''Acinetobacter calcoaceticus''<br /> | ||
| - | **[[1re5]] - PbMCI | + | **[[1re5]] - PbMCI <br /> |
| + | **[[1jof]] – MCI – ''Neurospora crassa''<br /> | ||
| + | **[[2fel]], [[2fen]] – MCI – ''Agrobacterium tumefaciens''<br /> | ||
*'''Dipeptide epimerase''' | *'''Dipeptide epimerase''' | ||
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**[[3dfy]] – TmMCI<br /> | **[[3dfy]] – TmMCI<br /> | ||
**[[3q45]], [[3q4d]] – MCI + Mg + dipeptide – ''Cytophaga hutchinsonii''<br /> | **[[3q45]], [[3q4d]] – MCI + Mg + dipeptide – ''Cytophaga hutchinsonii''<br /> | ||
| - | **[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus'' | + | **[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus''<br /> |
| + | **[[3jva]] – EfMCI + Mg – ''Enterococcus faecalis''<br /> | ||
| + | **[[3jw7]], [[3jzu]], [[3k1g]], [[3kum]] – EfMCI + Mg + dipeptide<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
| + | [[Category:Topic Page]] | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of muconate cycloisomerase
Updated on 10-November-2021
References
- ↑ Vollmer MD, Hoier H, Hecht HJ, Schell U, Groning J, Goldman A, Schlomann M. Substrate specificity of and product formation by muconate cycloisomerases: an analysis of wild-type enzymes and engineered variants. Appl Environ Microbiol. 1998 Sep;64(9):3290-9. PMID:9726873
- ↑ Schmidt E, Knackmuss HJ. Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid. Biochem J. 1980 Oct 15;192(1):339-47. PMID:7305906
- ↑ Ornston LN. The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. II. Enzymes of the protocatechuate pathway. J Biol Chem. 1966 Aug 25;241(16):3787-94. PMID:5916392
