Priyanka Basak/Sandbox

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== UreE: A Nickel Metallochaperone for Urease ==
 
==Introduction==
==Introduction==
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<StructureSection load='3tj8' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='3tj8' size='340' side='right' caption='''Hp''UreE,PDB ID: 1TJ8 ' scene=''>
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''Helicobacter pylori'' (''H.pylori'') is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. Several accessory proteins play a crucial role in the maturation of Urease. UreE is urease-specific Nickel metallochaperone that is involved in the delivery nickel to urease.
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UreE is an essential metallochaeprone for ''Helicobacter pylori'' (''H.pylori''). ''H.pylori'' is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment.
== Function ==
== Function ==
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UreE delivers Nickel to urease.
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Several accessory proteins play a crucial role in the maturation of Urease. UreE is a urease-specific nickel metallochaperone that is involved in the delivery nickel to urease.
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== Disease ==
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== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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Apo-UreE from ''H.pylori'' is a dimer which becomes tetrameric (dimer of dimer) when bound to metal. ''Hp''UreE can bind one Ni(II) and one Zn (II) per dimer. The nickel binding site is six-coordinate while the Zn is bound in a tetrahedral geometry.
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Apo-UreE from ''H.pylori'' is a dimer.''Hp''UreE can bind one Ni(II) per dimer <scene name='60/609775/Nickel_bound_uree/5'>Nickel bound UreE</scene>. Nickel is bound to UreE in an octahedral fashion with one His from one subunit and two His from other subunit <scene name='60/609775/Nickel_bound_uree_2/2'>(UreE-Nickel Binding site)</scene>.In presence of Ni, its oligomeric state changes to a tetramer (dimer of dimer).
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== Headline text ==
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<scene name='60/609775/Scene_1/1'>Nickel binding site</scene>This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
 
== References ==
== References ==
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<references/>
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<http://www.ncbi.nlm.nih.gov/pubmed/20681615/>
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Current revision

Introduction

PDB ID 3tj8

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Priyanka Basak

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