4kxz

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==crystal structure of tgfb2 in complex with GC2008.==
==crystal structure of tgfb2 in complex with GC2008.==
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<StructureSection load='4kxz' size='340' side='right' caption='[[4kxz]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
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<StructureSection load='4kxz' size='340' side='right'caption='[[4kxz]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kxz]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KXZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kxz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kv5|4kv5]], [[3eo1|3eo1]], [[3eo0|3eo0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kxz RCSB], [http://www.ebi.ac.uk/pdbsum/4kxz PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxz OCA], [https://pdbe.org/4kxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxz RCSB], [https://www.ebi.ac.uk/pdbsum/4kxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxz ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TGFB2_HUMAN TGFB2_HUMAN]] Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9. Defects in TGFB2 are the cause of Loeys-Dietz syndrome 4 (LDS4) [MIM:[http://omim.org/entry/614816 614816]]. An aortic aneurysm syndrome with widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae.<ref>PMID:22772368</ref>
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[https://www.uniprot.org/uniprot/TGFB2_HUMAN TGFB2_HUMAN] Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9. Defects in TGFB2 are the cause of Loeys-Dietz syndrome 4 (LDS4) [MIM:[https://omim.org/entry/614816 614816]. An aortic aneurysm syndrome with widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae.<ref>PMID:22772368</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TGFB2_HUMAN TGFB2_HUMAN]] TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
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[https://www.uniprot.org/uniprot/TGFB2_HUMAN TGFB2_HUMAN] TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4kxz" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mathieu, M]]
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[[Category: Homo sapiens]]
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[[Category: Moulin, A G]]
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[[Category: Large Structures]]
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[[Category: Wei, R]]
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[[Category: Mathieu M]]
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[[Category: Cysteine knot]]
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[[Category: Moulin AG]]
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[[Category: Fab]]
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[[Category: Wei R]]
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[[Category: Immune system]]
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[[Category: Tgf-beta receptor]]
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Current revision

crystal structure of tgfb2 in complex with GC2008.

PDB ID 4kxz

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