4x1v

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'''Unreleased structure'''
 
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The entry 4x1v is ON HOLD
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==Crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 76-91) from human ARAP1==
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<StructureSection load='4x1v' size='340' side='right'caption='[[4x1v]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4x1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X1V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1v OCA], [https://pdbe.org/4x1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x1v RCSB], [https://www.ebi.ac.uk/pdbsum/4x1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x1v ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN] Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3) [MIM:[https://omim.org/entry/607832 607832]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:12764198</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN] Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.<ref>PMID:15800069</ref>
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Authors: Rouka, E., Krojer, T., von Delft, F., Knapp, S., Kirsch, K.H., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Feller, S.M., Simister, P.C.
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==See Also==
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*[[CD2-associated protein 3D structures|CD2-associated protein 3D structures]]
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Description: Crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 76-91) from human ARAP1
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Edwards AM]]
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[[Category: Feller SM]]
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[[Category: Kirsch KH]]
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[[Category: Knapp S]]
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[[Category: Krojer T]]
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[[Category: Rouka E]]
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[[Category: Simister PC]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 76-91) from human ARAP1

PDB ID 4x1v

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