This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4rrs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:26, 8 March 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors==
==8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors==
-
<StructureSection load='4rrs' size='340' side='right' caption='[[4rrs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+
<StructureSection load='4rrs' size='340' side='right'caption='[[4rrs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4rrs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RRS FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4rrs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RRS FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UY:(4R,4AR,10AS)-8-(2-FLUOROPYRIDIN-3-YL)-4A-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[1,3-OXAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-2-AMINE'>3UY</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UY:(4R,4AR,10AS)-8-(2-FLUOROPYRIDIN-3-YL)-4A-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[1,3-OXAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-2-AMINE'>3UY</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r5n|4r5n]], [[4rrn|4rrn]], [[4rro|4rro]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrs OCA], [https://pdbe.org/4rrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rrs RCSB], [https://www.ebi.ac.uk/pdbsum/4rrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrs ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rrs RCSB], [http://www.ebi.ac.uk/pdbsum/4rrs PDBsum]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 16: Line 17:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4rrs" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Memapsin 2]]
+
[[Category: Homo sapiens]]
-
[[Category: Brown, K D]]
+
[[Category: Large Structures]]
-
[[Category: Burkard, M]]
+
[[Category: Brown KD]]
-
[[Category: Cox, A A]]
+
[[Category: Burkard M]]
-
[[Category: DeLisle, R K]]
+
[[Category: Cox AA]]
-
[[Category: Do, M K.Geck]]
+
[[Category: DeLisle RK]]
-
[[Category: Dutcher, D]]
+
[[Category: Dutcher D]]
-
[[Category: Groneberg, R]]
+
[[Category: Geck Do MK]]
-
[[Category: Hunt, K W]]
+
[[Category: Groneberg R]]
-
[[Category: Liao, J]]
+
[[Category: Hunt KW]]
-
[[Category: Liu, X]]
+
[[Category: Liao J]]
-
[[Category: Lyssikatos, J P]]
+
[[Category: Liu X]]
-
[[Category: Newhouse, B]]
+
[[Category: Lyssikatos JP]]
-
[[Category: Otten, J N]]
+
[[Category: Newhouse B]]
-
[[Category: Purkey, H E]]
+
[[Category: Otten JN]]
-
[[Category: Rana, S]]
+
[[Category: Purkey HE]]
-
[[Category: Regal, K]]
+
[[Category: Rana S]]
-
[[Category: Rhodes, S P]]
+
[[Category: Regal K]]
-
[[Category: Scearce-Levie, K]]
+
[[Category: Rhodes SP]]
-
[[Category: Siu, M]]
+
[[Category: Scearce-Levie K]]
-
[[Category: Smith, D]]
+
[[Category: Siu M]]
-
[[Category: Thomas, A A]]
+
[[Category: Smith D]]
-
[[Category: Vigers, G P.A]]
+
[[Category: Thomas AA]]
-
[[Category: Watts, R J]]
+
[[Category: Vigers GPA]]
-
[[Category: Wright, A D]]
+
[[Category: Watts RJ]]
-
[[Category: Aspartyl protease]]
+
[[Category: Wright AD]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+

Current revision

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

PDB ID 4rrs

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4rrs"
Personal tools