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1mgp

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[[Image:1mgp.gif|left|200px]]
 
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{{Structure
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==Hypothetical protein TM841 from Thermotoga maritima reveals fatty acid binding function==
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|PDB= 1mgp |SIZE=350|CAPTION= <scene name='initialview01'>1mgp</scene>, resolution 2.00&Aring;
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<StructureSection load='1mgp' size='340' side='right'caption='[[1mgp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PLM:PALMITIC ACID'>PLM</scene>
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<table><tr><td colspan='2'>[[1mgp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MGP FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mgp OCA], [https://pdbe.org/1mgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mgp RCSB], [https://www.ebi.ac.uk/pdbsum/1mgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mgp ProSAT], [https://www.topsan.org/Proteins/BSGC/1mgp TOPSAN]</span></td></tr>
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</table>
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'''Hypothetical protein TM841 from Thermotoga maritima reveals fatty acid binding function'''
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== Function ==
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[https://www.uniprot.org/uniprot/Y1468_THEMA Y1468_THEMA] Binds long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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We determined the three-dimensional (3D) crystal structure of protein TM841, a protein product from a hypothetical open-reading frame in the genome of the hyperthermophile bacterium Thermotoga maritima, to 2.0 A resolution. The protein belongs to a large protein family, DegV or COG1307 of unknown function. The 35 kDa protein consists of two separate domains, with low-level structural resemblance to domains from other proteins with known 3D structures. These structural homologies, however, provided no clues for the function of TM841. But the electron density maps revealed clear density for a bound fatty-acid molecule in a pocket between the two protein domains. The structure indicates that TM841 has the molecular function of fatty-acid binding and may play a role in the cellular functions of fatty acid transport or metabolism.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mg/1mgp_consurf.spt"</scriptWhenChecked>
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1MGP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MGP OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of a hypothetical protein, TM841 of Thermotoga maritima, reveals its function as a fatty acid-binding protein., Schulze-Gahmen U, Pelaschier J, Yokota H, Kim R, Kim SH, Proteins. 2003 Mar 1;50(4):526-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12577257 12577257]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mgp ConSurf].
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[[Category: Single protein]]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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[[Category: Kim R]]
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[[Category: Kim, R.]]
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[[Category: Kim S-H]]
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[[Category: Kim, S H.]]
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[[Category: Pelaschier J]]
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[[Category: Pelaschier, J.]]
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[[Category: Schulze-Gahmen U]]
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[[Category: Schulze-Gahmen, U.]]
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[[Category: Yokota H]]
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[[Category: Yokota, H.]]
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[[Category: PLM]]
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[[Category: berkeley structural genomics center]]
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[[Category: bsgc structure funded by nih]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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[[Category: two domain structure with mixed alpha/beta structures in both domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:43:11 2008''
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Current revision

Hypothetical protein TM841 from Thermotoga maritima reveals fatty acid binding function

PDB ID 1mgp

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