Porphobilinogen synthase

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{{STRUCTURE_1e51| PDB=1e51 | SIZE=400| SCENE= |right|CAPTION=Tetrameric human porphobilinogen synthase dimer with Zn+2 (small grey) complex with porphobilinogen and sulfate [[1e51]].}}
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<StructureSection load='' size='450' side='right' caption='Yeast porphobilinogen synthase complex with laevulunic acid and Zn+2 ion (grey) (PDB entry [[1h7n]])' scene='52/526179/Cv/1'>
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== Function ==
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'''Porphobilinogen synthase''' or '''δ-aminolaevulinic acid dehydratase''' (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of aminolaevulinic acid (ALA). PBS participates in porphyrin biosynthesis<ref>PMID:15381398</ref>. Levulinic acid (LA) is an inhibitor of PBS. Porphyrin is the precursor of hemes, chlorophyll and vitamin B12.
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'''Porphobilinogen synthase''' (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of aminolevulinic acid (ALA). PBS participates in porphyrin biosynthesis. Levulinic acid (LA) is an inhibitor of PBS. Porphyrin is the precursor of hemes, chlorophyll and vitamin B12. PBS deficiency can be caused by lead and other heavy metal poisoning.
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== Disease ==
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PBS deficiency can be caused by lead and other heavy metal poisoning<ref>PMID:7104498</ref>.
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===3D structures of porphobilinogen synthase===
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== Structural highlights ==
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The biological assembly of Yeast porphobilinogen synthase is <scene name='52/526179/Cv/4'>homooctamer</scene>. The <scene name='52/526179/Cv/5'>active site of PBS contains the substrate laevulinic acid and Zn+2 ion</scene><ref>PMID:11545591</ref>. Water molecules are shown as red spheres.
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</StructureSection>
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==3D structures of porphobilinogen synthase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Porphobilinogen synthase
*Porphobilinogen synthase
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**[[5hms]], [[5hnr]] – hPBS + Zn – human<br />
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**[[1pv8]] – hPBS (mutant)<br />
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**[[2z0i]], [[2z1b]] - PBS - mouse<br />
**[[1aw5]] – yPBS (mutant) + Zn – yeast<br />
**[[1aw5]] – yPBS (mutant) + Zn – yeast<br />
**[[1qml]] - yPBS + Hg<br />
**[[1qml]] - yPBS + Hg<br />
**[[1qnv]] - yPBS + Pb<br />
**[[1qnv]] - yPBS + Pb<br />
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**[[1pv8]] – hPBS (mutant) – human<br />
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**[[1w54]], [[1w56]], [[1w5m]], [[1w5n]], [[1w5o]], [[1w5p]], [[1w5q]] - PaPBS (mutant) + Mg + Zn – ''Pseudomonas aeruginosa''<br />
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**[[2z0i]], [[2z1b]] - PBS - mouse<br />
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**[[5lzl]] - PBS + Zn – ''Pyrobaculum calidifontis''<br />
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**[[1w54]], [[1w56]], [[1w5m]], [[1w5n]], [[1w5o]], [[1w5p]], [[1w5q]] - PaPBS (mutant) + Mg + Zn – ''Pseudomonas aeruginosa''
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*Porphobilinogen synthase complex
*Porphobilinogen synthase complex
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**[[1b4k]] - PaPBS + LA + Zn<br />
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**[[1e51]] - hPBS + PBG + Zn<br />
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**[[1b4e]] - EcPBS + LA + Zn – ''Escherichia coli''<br />
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**[[1ylv]], [[1h7n]] - yPBS + LA + Zn<br />
**[[1ylv]], [[1h7n]] - yPBS + LA + Zn<br />
**[[1w31]] - yPBS + LA derivative + Zn<br />
**[[1w31]] - yPBS + LA derivative + Zn<br />
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**[[1h7r]], [[1h7p]], [[1eb3]], [[1gjp]] - yPBS + inhibitor + Zn<br />
**[[1h7r]], [[1h7p]], [[1eb3]], [[1gjp]] - yPBS + inhibitor + Zn<br />
**[[1ohl]] - yPBS + intermediate + Zn<br />
**[[1ohl]] - yPBS + intermediate + Zn<br />
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**[[1b4e]] - EcPBS + LA + Zn – ''Escherichia coli''<br />
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**[[5mhb]] - EcPBS + PBG + Zn<br />
**[[1i8j]], [[1l6s]], [[1l6y]] - EcPBS + inhibitor + Mg + Zn<br />
**[[1i8j]], [[1l6s]], [[1l6y]] - EcPBS + inhibitor + Mg + Zn<br />
**[[2c1h]] - PBS + inhibitor + Mg – ''Chlorobium vibrioforme'' <br />
**[[2c1h]] - PBS + inhibitor + Mg – ''Chlorobium vibrioforme'' <br />
**[[2c13]], [[2c14]] - PaPBS (mutant) + inhibitor + Mg<br />
**[[2c13]], [[2c14]] - PaPBS (mutant) + inhibitor + Mg<br />
**[[2c15]], [[2c16]], [[2c18]], [[2c19]] - PaPBS + inhibitor + Mg<br />
**[[2c15]], [[2c16]], [[2c18]], [[2c19]] - PaPBS + inhibitor + Mg<br />
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**[[1e51]] - hPBS + PBG + Zn<br />
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**[[1b4k]] - PaPBS + LA + Zn<br />
**[[1gzg]] - PaPBS + LA derivative + Mg<br />
**[[1gzg]] - PaPBS + LA derivative + Mg<br />
**[[2woq]] - PaPBS + antibiotic + Mg<br />
**[[2woq]] - PaPBS + antibiotic + Mg<br />
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**[[1w1z]] - PBS + LA + Mg – ''Prosthecochloris vibrioformis''
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**[[1w1z]] - PBS + LA + Mg – ''Prosthecochloris vibrioformis''<br />
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**[[3obk]] - PBS residues 303-658 + Mg + PBG – ''Toxoplasma gondii''<br />
}}
}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Yeast porphobilinogen synthase complex with laevulunic acid and Zn+2 ion (grey) (PDB entry 1h7n)

Drag the structure with the mouse to rotate

3D structures of porphobilinogen synthase

Updated on 06-October-2020

References

  1. ↑ Jaffe EK. The porphobilinogen synthase catalyzed reaction mechanism. Bioorg Chem. 2004 Oct;32(5):316-25. PMID:15381398 doi:http://dx.doi.org/10.1016/j.bioorg.2004.05.010
  2. ↑ Doss M, Muller WA. Acute lead poisoning in inherited porphobilinogen synthase (delta-aminolevulinic acid dehydrase) deficiency. Blut. 1982 Aug;45(2):131-9. PMID:7104498
  3. ↑ Erskine PT, Newbold R, Brindley AA, Wood SP, Shoolingin-Jordan PM, Warren MJ, Cooper JB. The x-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors. J Mol Biol. 2001 Sep 7;312(1):133-41. PMID:11545591 doi:10.1006/jmbi.2001.4947

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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