We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

Preprotein translocase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:33, 12 September 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
<StructureSection load='2yxr' size='350' side='right' caption='Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry [[2yxr]])' scene=''>
<StructureSection load='2yxr' size='350' side='right' caption='Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry [[2yxr]])' scene=''>
 +
== Function ==
 +
'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor<ref>PMID:9489663</ref>. The translocase pathway contains:<br />
 +
*'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br />
 +
*'''SecY, SecE, SecG''' or '''Sec61''' an integral membrane complex<br />
 +
*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br />
 +
*'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br />
-
'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor. The translocase pathway contains a chaperone protein – '''SecB'''; an integral membrane complex – '''SecY, SecE, SecG;''' proteins promoting the release of the mature peptide into the periplasm – '''SecD, SecF'''; and ATPase unit - '''SecA'''. For more details see [[SecA PBD motions]].
+
For more details see [[SecA PBD motions]].
-
</StructureSection>
+
==3D structures of preprotein translocase==
==3D structures of preprotein translocase==
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
[[Preprotein translocase 3D structures]]
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
*Preprotein translocase SecY + SecE + SecB
+
== References ==
-
 
+
<references/>
-
**[[1rh5]], [[1rhz]] – MjPPT SecY + SecE + SecB – ''Methanocaldococcus jannaschii'' <br />
+
</StructureSection>
-
 
+
-
*Preprotein translocase SecY + SecE + SecG
+
-
 
+
-
**[[2akh]], [[2aki]] – EcPPT SecY + SecE + SecG – ''Escherichia coli'' - CryoEM <br />
+
-
**[[2yxq]], [[2yxr]] – MjPPT SecY + SecE + SecG <br />
+
-
**[[3dkn]] – PPT SecY + SecE + SecG + RNA – dog - CryoEM <br />
+
-
**[[3bo0]], [[3bo1]] – EcPPT SecY + SecE + SecG + 23S ribosomal RNA - CryoEM<br />
+
-
**[[3kcr]], [[3j45]], [[3j46]] – EcPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br />
+
-
**[[1vvk]] – MjPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br />
+
-
 
+
-
*Preprotein translocase SecY + SecE
+
-
 
+
-
**[[3mp7]] – PPT SecY + SecE – ''Pyrococcus furiosus'' <br />
+
-
**[[2zjs]] – TtPPT SecY + SecE + antibody – ''Thermus thermophilus''<br />
+
-
**[[2zqp]] – TtPPT SecY + SecE <br />
+
-
**[[3j01]] – EcPPT SecY + SecE + large ribosomal subunit - CryoEM<br />
+
-
 
+
-
*Preprotein translocase SecY + SecE + SecG + SecA
+
-
 
+
-
**[[3din]] – TmPPT SecY + SecE + SecG + SecA – ''Thermotoga maritima''<br />
+
-
**[[3dl8]] – PPT SecY + SecE + SecA + SecG – ''Aquifex aeolicus'' - CryoEM<br />
+
-
 
+
-
*Preprotein translocase SecA
+
-
 
+
-
**[[1m6n]], [[1tf5]], [[2ibm]] – BsPPT SecA – ''Bacillus subtilis'' <br />
+
-
**[[3iqm]], [[3iqy]] – BsPPT SecA (mutant)<br />
+
-
**[[1tm6]] – EcPPT SecA C terminal - NMR<br />
+
-
**[[2ipc]] – TtPPT SecA<br />
+
-
**[[3jux]] – TmPPT SecA<br />
+
-
**[[2fsf]] – EcPPT SecA<br />
+
-
**[[2fsf]] – EcPPT SecA<br />
+
-
**[[3bxz]] – EcPPT SecA dead motor domains (mutant)<br />
+
-
**[[1nl3]] – MtPPT SecA – ''Mycobacterium tuberculosis''<br />
+
-
 
+
-
*Preprotein translocase SecA complex
+
-
**[[1m74]], [[1tf2]] – BsPPT SecA + Mg + ADP <br />
 
-
**[[1ozb]] – PPT SecA C terminal + SecB - ''Haemophilus influenzae''<br />
 
-
**[[2fsh]] – EcPPT SecA + AMPPNP<br />
 
-
**[[2fsi]] – EcPPT SecA + ADP<br />
 
-
**[[2fsg]] – EcPPT SecA + ATP<br />
 
-
**[[2vda]] – EcPPT SecA + maltoporin signal peptide - NMR<br />
 
-
**[[3jv2]] – BsPPT SecA + peptide <br />
 
-
**[[1nkt]] – MtPPT SecA + ADP<br />
 
-
}}
 
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry 2yxr)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Preprotein_translocase"
Personal tools