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3j24
From Proteopedia
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==CryoEM reconstruction of complement decay-accelerating factor== | ==CryoEM reconstruction of complement decay-accelerating factor== | ||
| - | < | + | <SX load='3j24' size='340' side='right' viewer='molstar' caption='[[3j24]], [[Resolution|resolution]] 9.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3j24]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3j24]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J24 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j24 OCA], [https://pdbe.org/3j24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j24 RCSB], [https://www.ebi.ac.uk/pdbsum/3j24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j24 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3j24" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[CD55|CD55]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hafenstein SH]] |
| - | [[Category: | + | [[Category: Yoder JD]] |
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Current revision
CryoEM reconstruction of complement decay-accelerating factor
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