3j09

<StructureSection load='3j09' size='340' side='right' caption='[[3j09]], [[Resolution|resolution]] 10.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[3j09]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J09 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">copA, pacS, AF_0473 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j09 RCSB], [http://www.ebi.ac.uk/pdbsum/3j09 PDBsum]</span></td></tr>

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== Publication Abstract from PubMed ==

CopA uses ATP to pump Cu(+) across cell membranes. X-ray crystallography has defined atomic structures of several related P-type ATPases. We have determined a structure of CopA at 10 A resolution by cryo-electron microscopy of a new crystal form and used computational molecular docking to study the interactions between the N-terminal metal-binding domain (NMBD) and other elements of the molecule. We found that the shorter-chain lipids used to produce these crystals are associated with movements of the cytoplasmic domains, with a novel dimer interface and with disordering of the NMBD, thus offering evidence for the transience of its interaction with the other cytoplasmic domains. Docking identified a binding site that matched the location of the NMBD in our previous structure by cryo-electron microscopy, allowing a more detailed view of its binding configuration and further support for its role in autoinhibition.

 

The Architecture of CopA from Archeaoglobus fulgidus Studied by Cryo-Electron Microscopy and Computational Docking.,Allen GS, Wu CC, Cardozo T, Stokes DL Structure. 2011 Aug 3. PMID:21820315<ref>PMID:21820315</ref>

 

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*[[ATPase|ATPase]]

</StructureSection>

[[Category: Allen, G S]]

[[Category: Cardozo, T]]

[[Category: Stokes, D L]]

[[Category: Wu, C]]

[[Category: Adenosine triphosphatase]]

[[Category: P-type atpase]]