3guq

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==Crystal structure of novel carcinogenic factor of H. pylori==
==Crystal structure of novel carcinogenic factor of H. pylori==
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<StructureSection load='3guq' size='340' side='right' caption='[[3guq]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
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<StructureSection load='3guq' size='340' side='right'caption='[[3guq]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3guq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GUQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3guq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GUQ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HP0596, HP_0596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3guq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3guq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3guq RCSB], [http://www.ebi.ac.uk/pdbsum/3guq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3guq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3guq OCA], [https://pdbe.org/3guq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3guq RCSB], [https://www.ebi.ac.uk/pdbsum/3guq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3guq ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/O25318_HELPY O25318_HELPY]
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Stomach cancer is strongly associated with infection by Helicobacter pylori. In 2005, we identified a new H. pylori gene encoding a TNF-alpha inducing protein (Tipalpha) that acts as a carcinogenic factor. Tipalpha is secreted from H. pylori as a homodimer whose subunits are linked by disulfide bonds. We also characterized a Tipalpha deletion mutant (del-Tipalpha) that lacks the N-terminal six amino acid residues (LQACTC), including two cysteines (C5 and C7) that form disulfide bonds, but nonetheless shows a weak ability to induce TNF-alpha expression. Here we report that del-Tipalpha has a novel elongated structure containing a 40-A-long alpha helix, and forms a heart-shaped homodimer via non-covalent bonds. Moreover, their circular dichroism spectra strongly suggest that the structures of the del-Tipalpha and Tipalpha homodimers are very similar. del-Tipalpha's unique mode of dimer formation provides important insight into protein-protein interactions and into the mechanism underlying the carcinogenicity of H. pylori infection.
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Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein.,Tsuge H, Tsurumura T, Utsunomiya H, Kise D, Kuzuhara T, Watanabe T, Fujiki H, Suganuma M Biochem Biophys Res Commun. 2009 Oct 16;388(2):193-8. Epub 2009 Jul 28. PMID:19643085<ref>PMID:19643085</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Fujiki, H]]
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[[Category: Large Structures]]
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[[Category: Kise, D]]
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[[Category: Fujiki H]]
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[[Category: Kuzuhara, T]]
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[[Category: Kise D]]
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[[Category: Suganuma, M]]
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[[Category: Kuzuhara T]]
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[[Category: Tsuge, H]]
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[[Category: Suganuma M]]
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[[Category: Tsurumura, T]]
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[[Category: Tsuge H]]
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[[Category: Utsunomiya, H]]
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[[Category: Tsurumura T]]
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[[Category: Long alpha helix]]
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[[Category: Utsunomiya H]]
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[[Category: Novel carcinogenic factor]]
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[[Category: Tnfa inducing factor]]
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[[Category: Toxin]]
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Current revision

Crystal structure of novel carcinogenic factor of H. pylori

PDB ID 3guq

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