3gf9
From Proteopedia
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==Crystal structure of human Intersectin 2 RhoGEF domain== | ==Crystal structure of human Intersectin 2 RhoGEF domain== | ||
| - | <StructureSection load='3gf9' size='340' side='right' caption='[[3gf9]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3gf9' size='340' side='right'caption='[[3gf9]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3gf9]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3gf9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GF9 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf9 OCA], [https://pdbe.org/3gf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gf9 RCSB], [https://www.ebi.ac.uk/pdbsum/3gf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gf9 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/3gf9_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/3gf9_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gf9 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Intersectin|Intersectin]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bochkarev | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bochkarev A]] |
| - | [[Category: Edwards | + | [[Category: Bountra C]] |
| - | [[Category: Li | + | [[Category: Edwards AM]] |
| - | [[Category: Park | + | [[Category: Li Y]] |
| - | + | [[Category: Park H]] | |
| - | [[Category: Shen | + | [[Category: Shen Y]] |
| - | [[Category: Tempel | + | [[Category: Tempel W]] |
| - | [[Category: Tong | + | [[Category: Tong Y]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
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Current revision
Crystal structure of human Intersectin 2 RhoGEF domain
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Bountra C | Edwards AM | Li Y | Park H | Shen Y | Tempel W | Tong Y | Weigelt J
