This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1mtp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:48, 14 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1mtp.jpg|left|200px]]
 
-
{{Structure
+
==The X-ray crystal structure of a serpin from a thermophilic prokaryote==
-
|PDB= 1mtp |SIZE=350|CAPTION= <scene name='initialview01'>1mtp</scene>, resolution 1.5&Aring;
+
<StructureSection load='1mtp' size='340' side='right'caption='[[1mtp]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1mtp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermobifida_fusca Thermobifida fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MTP FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mtp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mtp OCA], [https://pdbe.org/1mtp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mtp RCSB], [https://www.ebi.ac.uk/pdbsum/1mtp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mtp ProSAT]</span></td></tr>
-
}}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q47NK3_THEFY Q47NK3_THEFY]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/1mtp_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mtp ConSurf].
 +
<div style="clear:both"></div>
-
'''The X-ray crystal structure of a serpin from a thermophilic prokaryote'''
+
==See Also==
-
 
+
*[[Serpin 3D structures|Serpin 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
Serpins utilize conformational change to inhibit target proteinases; the price paid for this conformational flexibility is that many undergo temperature-induced polymerization. Despite this thermolability, serpins are present in the genomes of thermophilic prokaryotes, and here we characterize the first such serpin, thermopin. Thermopin is a proteinase inhibitor and, in comparison with human alpha(1)-antitrypsin, possesses enhanced stability at 60 degrees C. The 1.5 A crystal structure reveals novel structural features in regions implicated in serpin folding and stability. Thermopin possesses a C-terminal "tail" that interacts with the top of the A beta sheet and plays an important role in the folding/unfolding of the molecule. These data provide evidence as to how this unusual serpin has adapted to fold and function in a heated environment.
+
[[Category: Large Structures]]
-
 
+
-
==About this Structure==
+
-
1MTP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermobifida_fusca Thermobifida fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTP OCA].
+
-
 
+
-
==Reference==
+
-
The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment., Irving JA, Cabrita LD, Rossjohn J, Pike RN, Bottomley SP, Whisstock JC, Structure. 2003 Apr;11(4):387-97. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12679017 12679017]
+
-
[[Category: Protein complex]]
+
[[Category: Thermobifida fusca]]
[[Category: Thermobifida fusca]]
-
[[Category: Bottomley, S P.]]
+
[[Category: Bottomley SP]]
-
[[Category: Cabrita, L D.]]
+
[[Category: Cabrita LD]]
-
[[Category: Irving, J A.]]
+
[[Category: Irving JA]]
-
[[Category: Pike, R N.]]
+
[[Category: Pike RN]]
-
[[Category: Rossjohn, J.]]
+
[[Category: Rossjohn J]]
-
[[Category: Whisstock, J C.]]
+
[[Category: Whisstock JC]]
-
[[Category: protease inhibitor]]
+
-
[[Category: structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:48:09 2008''
+

Current revision

The X-ray crystal structure of a serpin from a thermophilic prokaryote

PDB ID 1mtp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mtp"
Personal tools