1mvp

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[[Image:1mvp.gif|left|200px]]
 
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{{Structure
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==STRUCTURAL STUDIES OF THE RETROVIRAL PROTEINASE FROM AVIAN MYELOBLASTOSIS ASSOCIATED VIRUS==
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|PDB= 1mvp |SIZE=350|CAPTION= <scene name='initialview01'>1mvp</scene>, resolution 2.2&Aring;
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<StructureSection load='1mvp' size='340' side='right'caption='[[1mvp]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1mvp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_myeloblastosis-associated_virus Avian myeloblastosis-associated virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVP FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvp OCA], [https://pdbe.org/1mvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvp RCSB], [https://www.ebi.ac.uk/pdbsum/1mvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvp ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''STRUCTURAL STUDIES OF THE RETROVIRAL PROTEINASE FROM AVIAN MYELOBLASTOSIS ASSOCIATED VIRUS'''
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[https://www.uniprot.org/uniprot/GAG_AVIMA GAG_AVIMA] Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The structure of the retroviral proteinase from avian myeloblastosis associated virus (MAV) has been determined and refined at 2.2 A resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase-inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mv/1mvp_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1MVP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Avian_myeloblastosis_associated_virus Avian myeloblastosis associated virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVP OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mvp ConSurf].
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Structural studies of the retroviral proteinase from avian myeloblastosis associated virus., Ohlendorf DH, Foundling SI, Wendoloski JJ, Sedlacek J, Strop P, Salemme FR, Proteins. 1992 Nov;14(3):382-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1332025 1332025]
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<div style="clear:both"></div>
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[[Category: Avian myeloblastosis associated virus]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Foundling, S I.]]
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[[Category: Avian myeloblastosis-associated virus]]
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[[Category: Ohlendorf, D H.]]
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[[Category: Large Structures]]
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[[Category: Salemme, F R.]]
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[[Category: Foundling SI]]
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[[Category: hydrolase(aspartic proteinase)]]
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[[Category: Ohlendorf DH]]
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[[Category: Salemme FR]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:48:46 2008''
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Current revision

STRUCTURAL STUDIES OF THE RETROVIRAL PROTEINASE FROM AVIAN MYELOBLASTOSIS ASSOCIATED VIRUS

PDB ID 1mvp

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