3kwv

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==Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers==
==Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers==
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<StructureSection load='3kwv' size='340' side='right' caption='[[3kwv]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='3kwv' size='340' side='right'caption='[[3kwv]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kwv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KWV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kwv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KWV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.101&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pagA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis]), lef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase Anthrax lethal factor endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.83 3.4.24.83] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kwv OCA], [https://pdbe.org/3kwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kwv RCSB], [https://www.ebi.ac.uk/pdbsum/3kwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kwv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kwv RCSB], [http://www.ebi.ac.uk/pdbsum/3kwv PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3kwv" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Anthrax Lethal Factor|Anthrax Lethal Factor]]
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*[[Anthrax lethal factor 3D structures|Anthrax lethal factor 3D structures]]
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*[[Anthrax protective antigen|Anthrax protective antigen]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Anthrax lethal factor endopeptidase]]
 
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Feld, G K]]
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[[Category: Large Structures]]
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[[Category: Kintzer, A F]]
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[[Category: Feld GK]]
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[[Category: Krantz, B A]]
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[[Category: Kintzer AF]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Krantz BA]]
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[[Category: Hydrolase]]
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[[Category: Lethal factor]]
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[[Category: Lethal toxin]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Octamer]]
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[[Category: Protease]]
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[[Category: Protective antigen]]
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[[Category: Protein translocation]]
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[[Category: Protein transport]]
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[[Category: Protein unfolding]]
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[[Category: Secreted]]
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[[Category: Toxin]]
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[[Category: Toxin-protein transport complex]]
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[[Category: Virulence]]
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Current revision

Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers

PDB ID 3kwv

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