3m3z

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==Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor==
==Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor==
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<StructureSection load='3m3z' size='340' side='right' caption='[[3m3z]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3m3z' size='340' side='right'caption='[[3m3z]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3m3z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M3Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3m3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M3Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3F5:5-O-(2-AMINO-2-OXOETHYL)-8-(METHYLAMINO)ADENOSINE'>3F5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ldl|3ldl]], [[3ldn|3ldn]], [[3ldo|3ldo]], [[3ldp|3ldp]], [[3ldq|3ldq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3F5:5-O-(2-AMINO-2-OXOETHYL)-8-(METHYLAMINO)ADENOSINE'>3F5</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSPA8, HSC70, HSP73, HSPA10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BAG1, HAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3z OCA], [https://pdbe.org/3m3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m3z RCSB], [https://www.ebi.ac.uk/pdbsum/3m3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m3z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m3z RCSB], [http://www.ebi.ac.uk/pdbsum/3m3z PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3m3z" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[BAG protein|BAG protein]]
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*[[BAG family proteins 3D structures|BAG family proteins 3D structures]]
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*[[Heat Shock Proteins|Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dokurno, P]]
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[[Category: Large Structures]]
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[[Category: Macias, A T]]
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[[Category: Dokurno P]]
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[[Category: Massey, A J]]
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[[Category: Macias AT]]
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[[Category: Shaw, T]]
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[[Category: Massey AJ]]
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[[Category: Surgenor, A E]]
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[[Category: Shaw T]]
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[[Category: Williamson, D S]]
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[[Category: Surgenor AE]]
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[[Category: Adenosine]]
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[[Category: Williamson DS]]
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[[Category: Alternative initiation]]
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[[Category: Apoptosis]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Endoplasmatic reticulum]]
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[[Category: Grp78]]
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[[Category: Heat shock]]
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[[Category: Host-virus interaction]]
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[[Category: Hsc70]]
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[[Category: Hsp70]]
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[[Category: Nucleoside]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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[[Category: Protein folding]]
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[[Category: Selectivity]]
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[[Category: Small molecule inhibitor]]
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[[Category: Stress response]]
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Current revision

Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor

PDB ID 3m3z

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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