3mx2

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==Lassa fever virus Nucleoprotein complexed with dTTP==
==Lassa fever virus Nucleoprotein complexed with dTTP==
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<StructureSection load='3mx2' size='340' side='right' caption='[[3mx2]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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<StructureSection load='3mx2' size='340' side='right'caption='[[3mx2]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mx2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus Lassa virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MX2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mx2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MX2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.983&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mwp|3mwp]], [[3mwt|3mwt]], [[3mx5|3mx5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">N, Nucleoprotein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11620 Lassa virus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mx2 OCA], [https://pdbe.org/3mx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mx2 RCSB], [https://www.ebi.ac.uk/pdbsum/3mx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mx2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mx2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mx2 RCSB], [http://www.ebi.ac.uk/pdbsum/3mx2 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3mx2" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lassa virus]]
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[[Category: Large Structures]]
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[[Category: Dong, C]]
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[[Category: Lassa virus Josiah]]
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[[Category: Dong, H]]
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[[Category: Dong C]]
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[[Category: Lan, S]]
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[[Category: Dong H]]
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[[Category: Liang, Y]]
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[[Category: Lan S]]
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[[Category: Ly, H]]
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[[Category: Liang Y]]
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[[Category: Qi, X]]
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[[Category: Ly H]]
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[[Category: SSPF, Scottish Structural Proteomics Facility]]
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[[Category: Qi X]]
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[[Category: Schelde, L M]]
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[[Category: Schelde LM]]
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[[Category: Wallat, G]]
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[[Category: Wallat G]]
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[[Category: Wang, W]]
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[[Category: Wang W]]
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[[Category: Lassa fever virus]]
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[[Category: Nuclear protein]]
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[[Category: Nucleoprotein]]
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[[Category: Scottish structural proteomics facility]]
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[[Category: Sspf]]
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[[Category: Structural genomic]]
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Current revision

Lassa fever virus Nucleoprotein complexed with dTTP

PDB ID 3mx2

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