We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

3s7m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (02:23, 21 November 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Pyrazolyl and Thienyl Aminohydantoins as Potent BACE1 Inhibitors==
==Pyrazolyl and Thienyl Aminohydantoins as Potent BACE1 Inhibitors==
-
<StructureSection load='3s7m' size='340' side='right' caption='[[3s7m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+
<StructureSection load='3s7m' size='340' side='right'caption='[[3s7m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3s7m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S7M FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3s7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S7M FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=532:(5S)-2-AMINO-3-METHYL-5-[3-(PYRIDIN-3-YL)PHENYL]-5-(THIOPHEN-3-YL)-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE'>532</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s7l|3s7l]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=532:(5S)-2-AMINO-3-METHYL-5-[3-(PYRIDIN-3-YL)PHENYL]-5-(THIOPHEN-3-YL)-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE'>532</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7m OCA], [https://pdbe.org/3s7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s7m RCSB], [https://www.ebi.ac.uk/pdbsum/3s7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7m ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s7m RCSB], [http://www.ebi.ac.uk/pdbsum/3s7m PDBsum]</span></td></tr>
+
</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 17: Line 16:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3s7m" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Beta secretase|Beta secretase]]
+
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 25: Line 25:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Memapsin 2]]
+
[[Category: Large Structures]]
-
[[Category: Chopra, R]]
+
[[Category: Chopra R]]
-
[[Category: Olland, A]]
+
[[Category: Olland A]]
-
[[Category: Svenson, K]]
+
[[Category: Svenson K]]
-
[[Category: Aspartyl protease]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Endoplasmic reticulum]]
+
-
[[Category: Endosome]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Golgi apparatus]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Membrane]]
+
-
[[Category: Protease]]
+
-
[[Category: Transmembrane]]
+

Current revision

Pyrazolyl and Thienyl Aminohydantoins as Potent BACE1 Inhibitors

PDB ID 3s7m

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3s7m"
Personal tools