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1n59

From Proteopedia

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[[Image:1n59.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the Murine class I Major Histocompatibility Complex of H-2KB, B2-Microglobulin, and A 9-Residue immunodominant peptide epitope gp33 derived from LCMV==
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|PDB= 1n59 |SIZE=350|CAPTION= <scene name='initialview01'>1n59</scene>, resolution 2.95&Aring;
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<StructureSection load='1n59' size='340' side='right'caption='[[1n59]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1n59]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_mammarenavirus Lymphocytic choriomeningitis mammarenavirus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N59 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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|GENE= H2-K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n59 OCA], [https://pdbe.org/1n59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n59 RCSB], [https://www.ebi.ac.uk/pdbsum/1n59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n59 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n5/1n59_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n59 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the Murine class I Major Histocompatibility Complex of H-2KB, B2-Microglobulin, and A 9-Residue immunodominant peptide epitope gp33 derived from LCMV'''
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==See Also==
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[MHC 3D structures|MHC 3D structures]]
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==Overview==
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*[[MHC I 3D structures|MHC I 3D structures]]
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LCMV infection of H-2(b) mice generates a CD8(+) CTL response mainly directed toward three immunodominant epitopes. One of these, gp33, is presented by both H-2D(b) and H-2K(b) MHC class I molecules. The virus can escape immune recognition in the context of both these MHC class I molecules through single mutations of the peptide. In order to understand the underlying structural mechanism, we determined the crystal structures of both complexes. The structures reveal that the peptide is presented in two diametrically opposed manners by H-2D(b) and H-2K(b), with residues used as anchor positions in one MHC class I molecule interacting with the TCR in the other. Importantly, the peptide's N-terminal residue p1K protrudes from the binding cleft in H-2K(b). We present structural evidence that explains the functional consequences of single mutations found in escape variants.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1N59 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N59 OCA].
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[[Category: Lymphocytic choriomeningitis mammarenavirus]]
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==Reference==
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A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses., Achour A, Michaelsson J, Harris RA, Odeberg J, Grufman P, Sandberg JK, Levitsky V, Karre K, Sandalova T, Schneider G, Immunity. 2002 Dec;17(6):757-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12479822 12479822]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Achour A]]
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[[Category: Achour, A.]]
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[[Category: Grufman P]]
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[[Category: Grufman, P.]]
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[[Category: Harris RA]]
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[[Category: Harris, R A.]]
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[[Category: Karre K]]
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[[Category: Karre, K.]]
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[[Category: Levitsky V]]
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[[Category: Levitsky, V.]]
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[[Category: Michaelsson J]]
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[[Category: Michaelsson, J.]]
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[[Category: Odeberg J]]
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[[Category: Odeberg, J.]]
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[[Category: Sandalova T]]
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[[Category: Sandalova, T.]]
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[[Category: Sandberg JK]]
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[[Category: Sandberg, J K.]]
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[[Category: Schneider G]]
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[[Category: Schneider, G.]]
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[[Category: immunodominant epitope]]
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[[Category: lcmv]]
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[[Category: murine mhc]]
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[[Category: viral escape]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:52:17 2008''
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Current revision

Crystal structure of the Murine class I Major Histocompatibility Complex of H-2KB, B2-Microglobulin, and A 9-Residue immunodominant peptide epitope gp33 derived from LCMV

PDB ID 1n59

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