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1n6u

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[[Image:1n6u.gif|left|200px]]
 
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{{Structure
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==NMR structure of the interferon-binding ectodomain of the human interferon receptor==
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|PDB= 1n6u |SIZE=350|CAPTION= <scene name='initialview01'>1n6u</scene>
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<StructureSection load='1n6u' size='340' side='right'caption='[[1n6u]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1n6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N6U FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= IFNAR2 OR IFNARB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n6u OCA], [https://pdbe.org/1n6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n6u RCSB], [https://www.ebi.ac.uk/pdbsum/1n6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n6u ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INAR2_HUMAN INAR2_HUMAN] Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.<ref>PMID:8181059</ref> <ref>PMID:7665574</ref> <ref>PMID:7759950</ref> <ref>PMID:11682488</ref> <ref>PMID:12105218</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/1n6u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n6u ConSurf].
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<div style="clear:both"></div>
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'''NMR structure of the interferon-binding ectodomain of the human interferon receptor'''
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==See Also==
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*[[Interferon|Interferon]]
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*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
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==Overview==
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*[[Multiple sclerosis|Multiple sclerosis]]
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The potent antiviral and antiproliferative activities of human type I interferons (IFNs) are mediated by a single receptor comprising two subunits, IFNAR1 and IFNAR2. The structure of the IFNAR2 IFN binding ectodomain (IFNAR2-EC), the first helical cytokine receptor structure determined in solution, reveals the molecular basis for IFN binding. The atypical perpendicular orientation of its two fibronectin domains explains the lack of C domain involvement in ligand binding. A model of the IFNAR2-EC/IFNalpha2 complex based on double mutant cycle-derived constraints uncovers an extensive and predominantly aliphatic hydrophobic patch on the receptor that interacts with a matching hydrophobic surface of IFNalpha2. An adjacent motif of alternating charged side chains guides the two proteins into a tight complex. The binding interface may account for crossreactivity and ligand specificity of the receptor. This molecular description of IFN binding should be invaluable for study and design of IFN-based biomedical agents.
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== References ==
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<references/>
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==Disease==
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__TOC__
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Known disease associated with this structure: Hepatitis B virus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602376 602376]]
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</StructureSection>
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==About this Structure==
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1N6U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6U OCA].
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==Reference==
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The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding., Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J, Structure. 2003 Jul;11(7):791-802. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12842042 12842042]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Anglister, J.]]
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[[Category: Anglister J]]
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[[Category: Chill, J H.]]
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[[Category: Chill JH]]
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[[Category: Levy, R.]]
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[[Category: Levy R]]
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[[Category: Quadt, S R.]]
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[[Category: Quadt SR]]
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[[Category: Schreiber, G.]]
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[[Category: Schreiber G]]
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[[Category: fibronectin fold]]
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[[Category: immunoglobulin fold]]
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[[Category: two-domain structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:52:54 2008''
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Current revision

NMR structure of the interferon-binding ectodomain of the human interferon receptor

PDB ID 1n6u

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