3nfl

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==Crystal structure of the PTPN4 PDZ domain complexed with the C-terminus of the GluN2A NMDA receptor subunit==
==Crystal structure of the PTPN4 PDZ domain complexed with the C-terminus of the GluN2A NMDA receptor subunit==
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<StructureSection load='3nfl' size='340' side='right' caption='[[3nfl]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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<StructureSection load='3nfl' size='340' side='right'caption='[[3nfl]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nfl]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NFL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nfl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFL FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vph|2vph]], [[2cs5|2cs5]], [[3nfk|3nfk]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfl OCA], [https://pdbe.org/3nfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfl RCSB], [https://www.ebi.ac.uk/pdbsum/3nfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nfl RCSB], [http://www.ebi.ac.uk/pdbsum/3nfl PDBsum]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN]] Landau-Kleffner syndrome;Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation;Continuous spikes and waves during sleep;Rolandic epilepsy;Rolandic epilepsy - speech dyspraxia. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving GRIN2A has been found in a family with epilepsy and neurodevelopmental defects. Translocation t(16;17)(p13.2;q11.2). GRIN2A somatic mutations have been frequently found in cutaneous malignant melanoma, suggesting that the glutamate signaling pathway may play a role in the pathogenesis of melanoma.<ref>PMID:21499247</ref> <ref>PMID:24455489</ref>
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTN4_HUMAN PTN4_HUMAN]] May act at junctions between the membrane and the cytoskeleton. [[http://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
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[https://www.uniprot.org/uniprot/PTN4_HUMAN PTN4_HUMAN] May act at junctions between the membrane and the cytoskeleton.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3nfl" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Babault, N]]
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[[Category: Large Structures]]
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[[Category: Buc, H]]
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[[Category: Babault N]]
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[[Category: Cockburn, J]]
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[[Category: Buc H]]
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[[Category: Cordier, F]]
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[[Category: Cockburn J]]
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[[Category: Delepierre, M]]
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[[Category: Cordier F]]
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[[Category: Haouz, A]]
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[[Category: Delepierre M]]
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[[Category: Lafage, M]]
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[[Category: Haouz A]]
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[[Category: Lafon, M]]
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[[Category: Lafage M]]
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[[Category: Rey, F A]]
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[[Category: Lafon M]]
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[[Category: Wolff, N]]
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[[Category: Rey FA]]
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[[Category: Pdz-pdz-binding site complex]]
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[[Category: Wolff N]]
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[[Category: Protein binding]]
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Current revision

Crystal structure of the PTPN4 PDZ domain complexed with the C-terminus of the GluN2A NMDA receptor subunit

PDB ID 3nfl

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