1ncv

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[[Image:1ncv.gif|left|200px]]
 
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{{Structure
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==DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES==
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|PDB= 1ncv |SIZE=350|CAPTION= <scene name='initialview01'>1ncv</scene>
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<StructureSection load='1ncv' size='340' side='right'caption='[[1ncv]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ncv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NCV FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 7 models</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ncv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncv OCA], [https://pdbe.org/1ncv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ncv RCSB], [https://www.ebi.ac.uk/pdbsum/1ncv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ncv ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCL7_HUMAN CCL7_HUMAN] Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/1ncv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ncv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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MCP-3 is a beta chemokine consisting of 76 amino acid residues. It has been described to be involved in the activation of all leukocytic cells, activation mediated by the presence of multiple binding sites on the target cells. Its three-dimensional structure has been studied by making use of two-dimensional 1H NMR spectroscopy. MCP-3 exhibits the same monomeric structure as the other chemokines, i.e., a three-stranded antiparallel beta sheet covered on one face by an alpha helix. Although it belongs to the same subfamily as RANTES (Chung et al., 1995; Faitbrother et al., 1994) and hMIP-1beta (Lodi et al., 1994), the MCP-3 dimer is folded like IL-8 with the so-called alphabeta sandwich structural motif. Structural and sequence analysis gives clear indications suggesting that the other MCP chemokines may have the same quaternary structure, contrary to the other beta chemokines.
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'''DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES'''
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Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy.,Meunier S, Bernassau JM, Guillemot JC, Ferrara P, Darbon H Biochemistry. 1997 Apr 15;36(15):4412-22. PMID:9109648<ref>PMID:9109648</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ncv" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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MCP-3 is a beta chemokine consisting of 76 amino acid residues. It has been described to be involved in the activation of all leukocytic cells, activation mediated by the presence of multiple binding sites on the target cells. Its three-dimensional structure has been studied by making use of two-dimensional 1H NMR spectroscopy. MCP-3 exhibits the same monomeric structure as the other chemokines, i.e., a three-stranded antiparallel beta sheet covered on one face by an alpha helix. Although it belongs to the same subfamily as RANTES (Chung et al., 1995; Faitbrother et al., 1994) and hMIP-1beta (Lodi et al., 1994), the MCP-3 dimer is folded like IL-8 with the so-called alphabeta sandwich structural motif. Structural and sequence analysis gives clear indications suggesting that the other MCP chemokines may have the same quaternary structure, contrary to the other beta chemokines.
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*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
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== References ==
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==About this Structure==
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<references/>
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1NCV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCV OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy., Meunier S, Bernassau JM, Guillemot JC, Ferrara P, Darbon H, Biochemistry. 1997 Apr 15;36(15):4412-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9109648 9109648]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bernassau, J M.]]
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[[Category: Bernassau JM]]
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[[Category: Darbon, H.]]
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[[Category: Darbon H]]
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[[Category: Ferrara, P.]]
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[[Category: Ferrara P]]
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[[Category: Guillemot, J C.]]
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[[Category: Guillemot JC]]
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[[Category: Meunier, S.]]
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[[Category: Meunier S]]
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[[Category: beta-chemokine]]
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[[Category: chemotaxis]]
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[[Category: cytokine]]
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[[Category: glycoprotein]]
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[[Category: heparin-binding]]
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[[Category: mcp-3]]
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[[Category: nmr]]
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[[Category: structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:55:11 2008''
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Current revision

DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES

PDB ID 1ncv

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