3prm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:19, 6 November 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin==
==Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin==
-
<StructureSection load='3prm' size='340' side='right' caption='[[3prm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+
<StructureSection load='3prm' size='340' side='right'caption='[[3prm]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3prm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Crimean-congo_hemorrhagic_fever_virus Crimean-congo hemorrhagic fever virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PRM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3prm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Orthonairovirus_haemorrhagiae Orthonairovirus haemorrhagiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRM FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3CN:3-AMINOPROPANE'>3CN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4LJ:1.7.6+3-BROMANYLPROPAN-1-AMINE'>4LJ</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3prm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3prm OCA], [https://pdbe.org/3prm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3prm RCSB], [https://www.ebi.ac.uk/pdbsum/3prm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3prm ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3prm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3prm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3prm RCSB], [http://www.ebi.ac.uk/pdbsum/3prm PDBsum]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/L_CCHFI L_CCHFI] Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3prm" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Ubiquitin|Ubiquitin]]
+
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Crimean-congo hemorrhagic fever virus]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Ubiquitinyl hydrolase 1]]
+
[[Category: Large Structures]]
-
[[Category: Baker, E A]]
+
[[Category: Orthonairovirus haemorrhagiae]]
-
[[Category: Brunzelle, J S]]
+
[[Category: Baker EA]]
-
[[Category: Capodagli, G C]]
+
[[Category: Brunzelle JS]]
-
[[Category: Masters, E M]]
+
[[Category: Capodagli GC]]
-
[[Category: McKercher, M A]]
+
[[Category: Masters EM]]
-
[[Category: Pegan, S D]]
+
[[Category: McKercher MA]]
-
[[Category: Cysteine protease]]
+
[[Category: Pegan SD]]
-
[[Category: Deubiquitinase]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Hydrolase-hydrolase complex]]
+
-
[[Category: Ubiquitin hydrolase]]
+
-
[[Category: Viral protein]]
+

Current revision

Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin

PDB ID 3prm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3prm"
Personal tools